|
Psoriasis
|
|
0.850 |
GeneticVariation
|
BEFREE |
Collectively, these results implicate NETs and the Act1 D10N variant in human Th17 induction from peripheral blood mononuclear cells, with ramifications for immunogenetic studies of psoriasis and other autoimmune diseases.
|
30528823 |
2019 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
BEFREE |
Collectively, these results implicate NETs and the Act1 D</span>10N variant in human Th17 induction from peripheral blood mononuclear cells, with ramifications for immunogenetic studies of psoriasis and other autoimmune diseases.
|
30528823 |
2019 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
BEFREE |
We have replicated the association of TRAF3IP2-_rs33980500 variant with the susceptibility to psoriasis.
|
24005976 |
2014 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
BEFREE |
The hyperactive Th17 response combined with fully responsive fibroblasts likely synergized to contribute to psoriasis susceptibility in SNP-D10N patients.
|
25024377 |
2014 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
BEFREE |
By contrast, healthy individuals homozygous for the common variant D10N, located in the ACT1 tumor necrosis factor receptor-associated factor-interacting domain and previously associated with psoriasis, had impaired, but not abolished, responses to IL-17 cytokines.
|
24120361 |
2013 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
BEFREE |
In the absence of IL-17 signaling, IL-22 was the main contributor to skin inflammation, which provides a molecular mechanism for the association of Act1(D10N) with psoriasis susceptibility.
|
23202271 |
2013 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
Psoriasis
|
|
0.850 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
Arthritis, Psoriatic
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
Arthritis, Psoriatic
|
|
0.820 |
GeneticVariation
|
BEFREE |
However, the dominant PsA-associated TRAF3IP2 (Act1) gene single-nucleotide polymorphism (rs33980500) results in decreased binding of Act1 to TRAF6.
|
23116200 |
2012 |
|
Arthritis, Psoriatic
|
|
0.820 |
GeneticVariation
|
GWASDB |
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
|
20953186 |
2010 |
|
Arthritis, Psoriatic
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
|
20953186 |
2010 |
|
Arthritis, Psoriatic
|
|
0.820 |
GeneticVariation
|
BEFREE |
A stratified analysis of our datasets including only PsA cases (1,922 cases compared to 8,037 controls, P = 4.57 × 10⁻¹² for rs33980500) suggested that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
|
20953188 |
2010 |
|
Psoriasis vulgaris
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
Psoriasis vulgaris
|
|
0.710 |
GeneticVariation
|
BEFREE |
A stratified analysis of our datasets including only PsA cases (1,922 cases compared to 8,037 controls, P = 4.57 × 10⁻¹² for rs33980500) suggested that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
|
20953188 |
2010 |
|
PSORIASIS 13, SUSCEPTIBILITY TO
|
|
0.700 |
GeneticVariation
|
UNIPROT |
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
|
20953186 |
2010 |
|
PSORIASIS 13, SUSCEPTIBILITY TO
|
|
0.700 |
GeneticVariation
|
UNIPROT |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Collectively, these results implicate NETs and the Act1 D10N variant in human Th17 induction from peripheral blood mononuclear cells, with ramifications for immunogenetic studies of psoriasis and other autoimmune diseases.
|
30528823 |
2019 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
T allele of TRAF3IP2 rs33980500 was also associated with female gender, family history of cardiovascular disease, and mechanical complications of heart (P = .04, P = .02, and P = .01, respectively).
|
29430728 |
2018 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
To compare frequencies of functional polymorphisms of TRAF3IP2 (rs13210247, rs33980500) between patients with MI and healthy controls.
|
29430728 |
2018 |
|
Left Main Coronary Artery Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The highest correlation, however, was observed between the TRAF3IP2 rs33980500 TT genotype and T allele with left main coronary artery stenosis (P = .01, P < .001; OR = 31.03).
|
29430728 |
2018 |
|
Pustular psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses of clinically relevant phenotypes revealed association of rs33980500 with pustular psoriasis (OR = 1.2, p = 0.0109).
|
24005976 |
2014 |
|
Hyperactive behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lacking this compensatory mechanism, ACT1(D10N/D10N) T cells behave like ACT1-deficient T cells, exhibiting a dysregulated and hyperactive Th17 phenotype with overproduction of IL-22 and IL-17.
|
25024377 |
2014 |