|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results of genotype and allelic distribution of SNAP-25 rs363050 showed that AA genotype (AD versus HC: p = 1.5×10-4; MCI versus HC: p = 8.7×10-3) as well as A allele (AD versus HC: p = 6.0×10-4; MCI versus HC: p = 5.7×10-3) are significantly more frequent in AD and MCI compared to HC.
|
30958380 |
2019 |
|
Mild cognitive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, distribution of the STX1a rs4717806 allele in SNAP-25 rs363050 AA carriers was significantly different between MCI and HC (p = 0.018).
|
30958380 |
2019 |
|
Mild cognitive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Six different microRNAs (miR-181a-5p, miR-361-3p, miR-23a-3p, miR-15b-3p, 130a-3p and miR-27b-3p) that bind the SNAP-25 3'UTR region were measured by qPCR in serum of AD patients (<i>n</i> = 22), mild cognitive impairment (MCI) subjects (<i>n</i> = 22) and age- and sex-matched controls (<i>n</i> = 22); analysis of results was done stratified for the rs363050 SNAP-25 genotype.
|
30914946 |
2019 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results showed that the intronic rs363050 (A) and rs363043 (T) alleles, as well as the rs363050/rs363043 A-T haplotype are significantly more frequent in AD and aMCI and are associated with pathological scores of categorical fluency in AD.
|
25024311 |
2014 |
|
Mental deterioration
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent results showed that a reduction of SNAP-25 is associated with dementia, and that the rs363050 SNAP-25 polymorphism correlates with cognitive decline and brain atrophy, as well as with the outcome of multistructured rehabilitation in AD patients.
|
30914946 |
2019 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We assessed if genetic variants of the SNARE genes are associated with IHD.SNAP25 rs363050, Stx-1A rs4717806, rs2293489, and VAMP2 26bp ins/del genetic polymorphisms were analyzed in a cohort of 100 participants who underwent heart surgery; 56 of them were affected by IHD, while 44 were not.
|
31192914 |
2019 |
|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent results showed that a reduction of SNAP-25 is associated with dementia, and that the rs363050 SNAP-25 polymorphism correlates with cognitive decline and brain atrophy, as well as with the outcome of multistructured rehabilitation in AD patients.
|
30914946 |
2019 |
|
Brain atrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent results showed that a reduction of SNAP-25 is associated with dementia, and that the rs363050 SNAP-25 polymorphism correlates with cognitive decline and brain atrophy, as well as with the outcome of multistructured rehabilitation in AD patients.
|
30914946 |
2019 |
|
Cerebral atrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent results showed that a reduction of SNAP-25 is associated with dementia, and that the rs363050 SNAP-25 polymorphism correlates with cognitive decline and brain atrophy, as well as with the outcome of multistructured rehabilitation in AD patients.
|
30914946 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant associations were detected between rs363050 (AG/GG) genotypes and increasing fasting glucose levels (p = 0.01 and OR: 1.05), HbA1c levels (OR: 5.06 and p = 0.02), and lower insulinemia (p = 0.03 and OR: 0.95) in T2DM patients.
|
26779543 |
2016 |