|
Osteoarthritis, Knee
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs3740199 G/C polymorphism was found to be associated with increased KOA risk in men (e.g., CG versus GG: OR = 1.44, 95% CI = 1.02-2.04, <i>P</i> = 0.040), but not in the overall analysis and in analyses of other subgroups.
|
29100419 |
2017 |
|
Osteoarthritis, Knee
|
|
0.050 |
GeneticVariation
|
BEFREE |
Based on the findings of our study, there was a modest but statistically significant association between rs1871054 and risk of KOA in Asian population, while other polymorphisms (rs3740199, rs1044122, or rs1278279) in ADAM12 were not associated with KOA in any population.
|
28929114 |
2017 |
|
Osteoarthritis, Knee
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that the rs3740199 polymorphism does not contribute to the development of knee OA.
|
28637509 |
2017 |
|
Osteoarthritis, Knee
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs3740199 polymorphism of the ADAM12 gene can potentially be used to determine genetically high-risk subgroup of knee osteoarthritis and to better understand the pathogenesis of knee osteoarthritis.
|
26875044 |
2016 |
|
Osteoarthritis, Knee
|
|
0.050 |
GeneticVariation
|
BEFREE |
Two thousand four hundred and sixty-two subjects aged 50 years and older were assessed for OA at the knee, were genotyped with two SNPs (GDF5; rs143383 and ADAM12; rs3740199).
|
22284607 |
2012 |
|
Degenerative polyarthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the stratified analysis by gender, significant association was identified with the risk of knee OA for rs3740199 in men in allele model (OR 2.41, 95% CI 1.51-3.84, P < 0.001), dominant model (OR 2.68, 95% CI 1.17-6.14, P = 0.02) and recessive model (OR 3.51, 95% CI 1.68-7.36, P = 0.001), but not for additive model (OR 1.30, 95% CI 0.81-2.08, P = 0.28).
|
28748424 |
2017 |
|
Degenerative polyarthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs3740199 in ADAM12 was associated with knee OA susceptibility in Thai male patients, and individuals with the CC genotype carried the highest risk when compared with the GG and GC genotypes.
|
26875044 |
2016 |
|
Degenerative polyarthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We conclude that rs3740199 polymorphism may affect occurrence of knee OA and its progression.
|
19268722 |
2009 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with the ADAM12 (rs3740199) CC genotype were at increased risk for moderate and severe asthma.
|
26553447 |
2016 |