Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
BEFREE |
Among 124 876 cases and controls, genome-wide conjunction analyses of ALS, FTD, PD, AD, CBD, and PSP revealed significant genetic overlap between ALS and FTD at known ALS loci: rs13302855 and rs3849942 (nearest gene, C9orf72; P = .03 for rs13302855 and P = .005 for rs3849942) and rs4239633 (nearest gene, UNC13A; P = .03).
|
29630712 |
2018 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
BEFREE |
We performed a replication study of the 2 genetic variants, rs34517613 on 17q11.2 and rs3849942 on 9p21.2 in patients with sporadic amyotrophic lateral sclerosis (ALS) and Parkinson's disease in a Chinese population.
|
26304631 |
2015 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
BEFREE |
Genome-wide association testing was performed first using all samples, and then restricting the analysis to samples not carrying the mutation. rs3849942 and rs903603 were strongly associated with ALS when all samples were included (rs3849942, p = [3 × 2] × 10(-6), rank 7/442,057; rs903603, p = [7 × 6] × 10(-8), rank 2/442,057).
|
23587638 |
2013 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
BEFREE |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASDB |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association testing was performed first using all samples, and then restricting the analysis to samples not carrying the mutation. rs3849942 and rs903603 were strongly associated with ALS when all samples were included (rs3849942, p = [3 × 2] × 10(-6), rank 7/442,057; rs903603, p = [7 × 6] × 10(-8), rank 2/442,057).
|
23587638 |
2013 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASCAT |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
BEFREE |
All expansion-positive patients were genotyped for rs3849942, a surrogate marker for the chromosome 9p21 risk haplotype previously associated with FTD and ALS.
|
22875086 |
2012 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
BEFREE |
In the joint analysis, which included samples from 4312 patients with ALS and 8425 control individuals, rs3849942</span> (p=4·64×10(-10); OR 1·22, 95% CI 1·15-1·30) and rs2814707 (p=4·72×10(-10); 1·22, 1·15-1·30) were associated with ALS.
|
20801717 |
2010 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASDB |
In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).
|
20801717 |
2010 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASCAT |
In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).
|
20801717 |
2010 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASDB |
The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10(-11)) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS.
|
20801718 |
2010 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASCAT |
The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10(-11)) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS.
|
20801718 |
2010 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
BEFREE |
The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10(-11)) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS.
|
20801718 |
2010 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASCAT |
In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).
|
20801717 |
2010 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
Amyotrophic Lateral Sclerosis, Sporadic
|
|
0.710 |
GeneticVariation
|
BEFREE |
We performed a replication study of the 2 genetic variants, rs34517613 on 17q11.2 and rs3849942 on 9p21.2 in patients with sporadic amyotrophic lateral sclerosis (ALS) and Parkinson's disease in a Chinese population.
|
26304631 |
2015 |
Amyotrophic Lateral Sclerosis, Sporadic
|
|
0.710 |
GeneticVariation
|
GWASCAT |
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis.
|
24256812 |
2014 |
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis.
|
24256812 |
2014 |
AMYOTROPHIC LATERAL SCLEROSIS 1
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis.
|
24256812 |
2014 |
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis.
|
24256812 |
2014 |
Prion Diseases
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
|
22210626 |
2012 |
Frontotemporal dementia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Among 124 876 cases and controls, genome-wide conjunction analyses of ALS, FTD, PD, AD, CBD, and PSP revealed significant genetic overlap between ALS and FTD at known ALS loci: rs13302855 and rs3849942 (nearest gene, C9orf72; P = .03 for rs13302855 and P = .005 for rs3849942) and rs4239633 (nearest gene, UNC13A; P = .03).
|
29630712 |
2018 |
Frontotemporal dementia
|
|
0.020 |
GeneticVariation
|
BEFREE |
All expansion-positive patients were genotyped for rs3849942, a surrogate marker for the chromosome 9p21 risk haplotype previously associated with FTD and ALS.
|
22875086 |
2012 |