rs387906656, MYH6

N. diseases: 6
Disease: Sick Sinus Syndrome ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Sick Sinus Syndrome
CUI: C0037052
Disease: Sick Sinus Syndrome
0.030 GeneticVariation BEFREE We have previously reported broad effects of p.Arg721Trp on cardiac electrical function and strong association with sick sinus syndrome and atrial fibrillation. 29590334 2018
Sick Sinus Syndrome
CUI: C0037052
Disease: Sick Sinus Syndrome
0.030 GeneticVariation BEFREE Moreover, a rare MYH6 variant, R721W, predisposing susceptibility to sick sinus syndrome has been identified. 25717017 2015
Sick Sinus Syndrome
CUI: C0037052
Disease: Sick Sinus Syndrome
0.030 GeneticVariation BEFREE We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant. 21378987 2011