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DIABETES MELLITUS, INSULIN-DEPENDENT, 10
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|
0.700 |
GeneticVariation
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CLINVAR |
|
|
|
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Diabetes Mellitus, Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that all five SNPs in the IL2RA gene are risk factors for T1D risk, and rs11594656, rs2104286 and rs41295061 are the most associated SNPs in the populations investigated.
|
26249556 |
2015 |
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Diabetes Mellitus, Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
The reported association with T1D patients of the IL2RA-rs41295061 located in the 10p15 region was replicated and our data suggest a trend of association of the polymorphisms IL2-rs17388568 and IL2-rs6822844 in 4q27.
|
21875375 |
2011 |
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Diabetes Mellitus, Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
The most associated T1D SNP (rs41295061) was not associated with MS in the present study.
|
19125193 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
We show that SLE is associated with rs11594656 (P = 3.87 x 10-7) and there is some evidence of association of rs41295061 with AAV (P = 0.0122), which both have prior association with T1D. rs2104286, an MS and T1D - associated SNP in the IL2RA locus, is not associated with either SLE or AAV.
|
19265545 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
We had previously shown rs3118470 to confer T1D susceptibility in a Canadian dataset, independently of rs41295061 as the major reported locus (p = 5 x 10(-3), after accounting for rs41295061 by conditional regression).
|
19794070 |
2009 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The most associated T1D SNP (rs41295061) was not associated with MS in the present study.
|
19125193 |
2009 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We show that SLE is associated with rs11594656 (P = 3.87 x 10-7) and there is some evidence of association of rs41295061 with AAV (P = 0.0122), which both have prior association with T1D. rs2104286, an MS and T1D - associated SNP in the IL2RA locus, is not associated with either SLE or AAV.
|
19265545 |
2009 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL2RA polymorphism was associated with liver cirrhosis (rs41295061, OR=1.76, P=0.033) whereas the MMEL1 polymorphism increased the risk of requiring liver transplantation (rs2843403, OR=1.70, P=0.023).
|
28922436 |
2017 |
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Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A minor allele A of rs41295061 showed significant association with increased risk of GD [odds ratio (OR) = 1.43, P(c) = 0.00102].
|
21815908 |
2011 |
|
Autoimmune Diseases
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|
0.010 |
GeneticVariation
|
BEFREE |
Using a cohort of over 700 AAV patients, two SLE case-control studies and an SLE trio collection (totalling over 1000 SLE patients), and a TaqMan genotyping approach, we tested 3 SNPs in the IL2RA locus, rs11594656, rs2104286 & rs41295061, each with a prior association with autoimmune disease; rs11594656 and rs41295061 with type 1 diabetes (T1D) and rs2104286 with multiple sclerosis (MS) and T1D.
|
19265545 |
2009 |
|
Juvenile arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A second SNP (rs41295061) also showed modest evidence for association with JIA (OR 0.80 [95% CI 0.63-1.0], P=0.05).
|
19116909 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
We show that SLE is associated with rs11594656 (P = 3.87 x 10-7) and there is some evidence of association of rs41295061 with AAV (P = 0.0122), which both have prior association with T1D. rs2104286, an MS and T1D - associated SNP in the IL2RA locus, is not associated with either SLE or AAV.
|
19265545 |
2009 |