|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.820 |
GeneticVariation
|
BEFREE |
IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study.
|
31604453 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.820 |
GeneticVariation
|
BEFREE |
IKZF1 rs4132601 polymorphism and acute lymphoblastic leukemia susceptibility: a meta-analysis.
|
25012940 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
|
22076464 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.820 |
GeneticVariation
|
GWASDB |
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.
|
19684604 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.
|
19684604 |
2009 |
|
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
|
29632299 |
2018 |
|
Nasopharyngeal carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
LEUKEMIA, ACUTE LYMPHOBLASTIC, SUSCEPTIBILITY TO, 2
|
|
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.
|
31604453 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, a borderline association was found between IKZF1 rs4132601 T>G variant and ALL risk.
|
28768142 |
2017 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings provide the rst evidence that SNPs ARID5B- rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children.
|
27644650 |
2016 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the other hand, the rs4132601 G allele increased the risk of ALL (OR = 1.86, 95 % CI = 1.28-2.96; p = 0.0011) in comparison with the T allele.
|
26790447 |
2016 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results, which are consistent with findings in European populations, show that 3 SNPs, i.e., rs4132601 (P = .00116, odds ratio [OR] = 2.78, 95% confidence interval [CI] = [1.42, 5.87]), rs7089424 (P = .0022, OR = 0.49, 95% CI = [0.31, 0.79]), and rs2239633 (P = .0010, OR = 0.47, 95% CI = [0.29, 0.75]) are significantly associated with a higher risk of developing pediatric ALL (P < .05).
|
27184773 |
2016 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These SNPs are located at CDKN2A (rs3731217) and IKZF1 (rs4132601), genes frequently lost in ALL, and at CEBPE (rs2239633), ARID5B (rs7089424), PIP4K2A (rs10764338), and GATA3 (rs3824662), genes located on chromosomes gained in high-hyperdiploid ALL.
|
26575185 |
2015 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggested that rs4132601 was associated with an increased ALL risk.
|
25012940 |
2015 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results of the analysis provide statistically significant support for an association between the rs4132601 polymorphic site and age at diagnosis of childhood ALL (p = 0.04).
|
24597983 |
2014 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Consistent with findings in European populations, rs4132601 genotype was significantly associated with risk of ALL (odds ratio [OR] = 1.57, 95% confidence interval [CI]: 1.01-2.44; p = 0.04), and rs10821938 genotype was significantly associated with B-cell precursor ALL (OR = 0.73, 95% CI: 0.55-0.97; p = 0.03).
|
20919861 |
2010 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 x 10(-7)).
|
19684604 |
2009 |
|
Acute lymphocytic leukemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.
|
31604453 |
2019 |
|
Acute lymphocytic leukemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
IKZF1 rs4132601 and rs10272724 could be considered significant risk contributors to childhood acute lymphoblastic leukaemia and may impact the iron profiles in these children.
|
30806315 |
2019 |
|
Acute lymphocytic leukemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
In addition, a borderline association was found between IKZF1 rs4132601 T>G variant and ALL risk.
|
28768142 |
2017 |
|
Acute lymphocytic leukemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The results suggested that rs4132601 was associated with an increased ALL risk.
|
25012940 |
2015 |
|
Acute lymphocytic leukemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
Results of the analysis provide statistically significant support for an association between the rs4132601 polymorphic site and age at diagnosis of childhood ALL (p = 0.04).
|
24597983 |
2014 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.
|
31604453 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
In addition, a borderline association was found between IKZF1 rs4132601 T>G variant and ALL risk.
|
28768142 |
2017 |