|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The IGF2BP2 rs1470579 and rs4402960 polymorphisms may be associated with the development of T2DM, and these polymorphisms may affect the therapeutic efficacy of repaglinide in Chinese T2DM patients.
|
20523342 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05].
|
24993573 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that rs4402960 polymorphism in IGF2BP2 is associated with elevated T2D risk, but these associations vary in different ethnic populations.
|
22032244 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASCAT |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
18372903 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that IGF2BP2 rs4402960 polymorphism conferred elevated risk of T2DM, especially in European, East Asian and South Asian populations.
|
21839790 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASDB |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11.
|
22569928 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index.
|
20509872 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASCAT |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
22693455 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
When combined, each additional risk allele from CDKAL1-rs9465871, CDKN2A/B-rs10811661, IGF2BP2-rs4402960, and SLC30A8-rs13266634 increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)).
|
18633108 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The rs4402960 polymorphisms were significantly associated with the T2DM risk after stratification by diagnostic criterion, size of sample and average age and BMI of cases, while there're no consistent results for rs1470579.
|
27294943 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The association of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) common variants (rs4402960 and rs1470579) with type 2 diabetes (T2D) has been performed in different populations.
|
23029108 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASCAT |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
The risk associated with the presence of T2D was modified both by IGF2BP2_rs4402960 and PPARγ_rs1801282 SNP (P(interaction) = 0.04 and 0.04, respectively).
|
22419714 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (<i>TCF7L2</i> rs7901695, <i>FTO</i> rs8050136, <i>HHEX</i> rs5015480, <i>SLC30A8</i> rs13266634 and <i>IGF2BP2</i> rs4402960) were observed in this study population.
|
28067832 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A total of 15 SNPs were genotyped.Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05-1.27); P = 4.5 x 10(-3)] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14-1.40); P = 1.4 x 10(-5)] and rs7923837 [OR = 1.27 (95% CI 1.13-1.43); P = 1.0 x 10(-4)] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15-1.40); P = 1.9 x 10(-6)] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11-1.36); P = 8.1 x 10(-5)] and rs1470579 [OR = 1.18 (95% CI 1.07-1.31); P = 8.3 x 10(-4)] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17-1.41); P = 4.5 x 10(-7)] and rs7756992 [OR = 1.27 (95% CI 1.15-1.40); P = 9.8 x 10(-7)] in CDKAL1.
|
18477659 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
We replicated the association of T2D risk with I<i>GF2BP</i> rs4402960 and detected novel associations with <i>TERT</i> rs2735940 and rs2736098.
|
29410390 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
SusceptibilityMutation
|
CLINVAR |
|
|
|