rs4487645, DNAH11

N. diseases: 3
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Multiple Myeloma
CUI: C0026764
Disease: Multiple Myeloma
0.810 GeneticVariation BEFREE Common single-nucleotide polymorphisms (SNPs) at 2p23.3 (rs6746082), 3p22.1 (rs1052501), 3q26.2 (rs10936599), 6p21.33 (rs2285803), 7p15.3 (rs4487645), 17p11.2 (rs4273077), and 22q13.1 (rs877529) have recently been shown to influence MM risk. 24449210 2014
Multiple Myeloma
CUI: C0026764
Disease: Multiple Myeloma
0.810 GeneticVariation GWASDB The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. 23502783 2013
Multiple Myeloma
CUI: C0026764
Disease: Multiple Myeloma
0.810 GeneticVariation GWASDB Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. 23955597 2013
Multiple Myeloma
CUI: C0026764
Disease: Multiple Myeloma
0.810 GeneticVariation GWASCAT The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. 23502783 2013
Multiple Myeloma
CUI: C0026764
Disease: Multiple Myeloma
0.810 GeneticVariation GWASDB We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). 22120009 2011
Multiple Myeloma
CUI: C0026764
Disease: Multiple Myeloma
0.810 GeneticVariation GWASCAT We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). 22120009 2011
Primary amyloidosis
CUI: C0268381
Disease: Primary amyloidosis
0.700 GeneticVariation GWASCAT Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma. 28025584 2017
Monoclonal Gammopathy of Undetermined Significance
CUI: C0026470
Disease: Monoclonal Gammopathy of Undetermined Significance
0.010 GeneticVariation BEFREE Each SNP independently influenced MGUS risk with statistically significant associations (P < .02) for rs1052501, rs2285803, rs4487645, and rs4273077. 24449210 2014