rs4532, DRD1

N. diseases: 7
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.020 GeneticVariation BEFREE Previous association results between dopamine D1 receptor (DRD1) rs4532 polymorphism and antipsychotic treatment response in schizophrenia and schizoaffective subjects have been conflicting. 26213377 2015
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.020 GeneticVariation BEFREE We investigated the association of dopamine receptor D1 gene (DRD1) rs4532 polymorphism with antipsychotic treatment response in schizophrenia. 23036699 2012
Alcohol Use Disorder
CUI: C0001956
Disease: Alcohol Use Disorder
0.010 GeneticVariation BEFREE Five single nucleotide polymorphisms (SNPs) (rs4532 in DRD1, rs2283265 in DRD2, rs6280 in DRD3, rs1800497 in ANKK1, and rs4680 in COMT) and a variable number of tandem repeats (VNTRs) in DAT1 in 295 male patients with AUD were genotyped. 31559529 2019
Impulsive Behavior
CUI: C0021125
Disease: Impulsive Behavior
0.010 GeneticVariation BEFREE In regard to impulsivity and aggressiveness, rs4532 of DRD1 was significantly associated with UPPS-P score. 31559529 2019
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.010 GeneticVariation BEFREE In the dominant model, rs4532 locus of DRD1 gene was related to hypertension with a pooled OR of 1.353 (95% CI =1.016-1.802, P=0.038). 26730182 2016
Drug-induced tardive dyskinesia
CUI: C3714760
Disease: Drug-induced tardive dyskinesia
0.010 GeneticVariation BEFREE Haplotype frequency (%) CGC of rs5326-rs45</span>32-rs265975 (TD: non-TD) was 19.0:13.7; and after haplotype-based analyses, haplotype CGC also showed significant association with TD (OR=1.4, permutation P=0.027). 21181138 2011
Tardive Dyskinesia
CUI: C0686347
Disease: Tardive Dyskinesia
0.010 GeneticVariation BEFREE Haplotype frequency (%) CGC of rs5326-rs45</span>32-rs265975 (TD: non-TD) was 19.0:13.7; and after haplotype-based analyses, haplotype CGC also showed significant association with TD (OR=1.4, permutation P=0.027). 21181138 2011
Nicotine Dependence
CUI: C0028043
Disease: Nicotine Dependence
0.010 GeneticVariation BEFREE Although we found significant associations of SNPs rs265973, rs686, and rs4532 in the AA sample; of rs4532 in the EA sample; and of rs265975, rs686, and rs4532 in the pooled sample with various ND measures, only the association of rs686 in the AA sample and of rs686 and rs4532 in the pooled sample remained significant after correction for multiple testing. 18092181 2008