|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The homozygous minor allele (AA) of CYP19A1 rs4646 is significantly associated with improved clinical outcome of hormone therapy in premenopausal HR-positive early breast cancer patients, but with a worse impact on postmenopausal women.
|
26191232 |
2015 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study indicates that CYP19 rs464</span>6 polymorphism is related to DFS in early breast cancer and that the prognosis index of the homozygous for the minor allele (AA) may depend on menopause status.
|
25793413 |
2015 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the presence of the rs4646 variant may be a predictive factor of the benefit of AI treatment for BC.
|
26067721 |
2015 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping for the CYP19 polymorphisms rs4646 (A/C), rs1065779 (A/C), CYP19 (TTTA)n (short allele/long (S/L) allele using the 7 TTTA repeat polymorphism as the cut-off), and rs1870050 (A/C) was performed on 296 patients with LN-negative, HR-positive breast cancers.
|
24324964 |
2013 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The common allele of rs4646, which has been associated with increased breast cancer risk, was associated with low-histological grade and small tumour size (P = 0.001 and 0.015; 1-sided, respectively).
|
20960227 |
2011 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Testing for the rs4646 polymorphism could be a useful tool in order to orientate the treatment in elderly BC patients.
|
20144226 |
2010 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common haplotype composed of the Val(80) G allele and three haplotype-tagging single nucleotide polymorphisms (rs727479, rs10046, and rs4646) in the CYP19 coding region showed a trend to association with breast cancer risk in BRCA1 carriers ages <50 years.
|
19366906 |
2009 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNPs rs10046 and rs4646 may influence the HER2 status of breast cancer tumors, and rs10046 genotypes are associated with an altered DFS.
|
18049890 |
2008 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Testing for the CYP19 rs4646 SNP as a predictive tool for breast cancer patients on antiaromatase therapy deserves prospective evaluation.
|
18245543 |
2008 |
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a case-control study nested within a breast self-examination trial conducted in China, we examined whether CYP19A1 polymorphisms (rs1870049, rs1004982, rs28566535, rs936306, rs11636639, rs767199, rs4775936, rs11575899, rs10046, and rs4646) were associated with risk of breast cancer and fibrocystic breast conditions.
|
19064562 |
2008 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The present study indicates that CYP19 rs464</span>6 polymorphism is related to DFS in early breast cancer and that the prognosis index of the homozygous for the minor allele (AA) may depend on menopause status.
|
25793413 |
2015 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
These findings suggest that the presence of the rs4646 variant may be a predictive factor of the benefit of AI treatment for BC.
|
26067721 |
2015 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The homozygous minor allele (AA) of CYP19A1 rs4646 is significantly associated with improved clinical outcome of hormone therapy in premenopausal HR-positive early breast cancer patients, but with a worse impact on postmenopausal women.
|
26191232 |
2015 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
The common allele of rs4646, which has been associated with increased breast cancer risk, was associated with low-histological grade and small tumour size (P = 0.001 and 0.015; 1-sided, respectively).
|
20960227 |
2011 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Testing for the rs4646 polymorphism could be a useful tool in order to orientate the treatment in elderly BC patients.
|
20144226 |
2010 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
A common haplotype composed of the Val(80) G allele and three haplotype-tagging single nucleotide polymorphisms (rs727479, rs10046, and rs4646) in the CYP19 coding region showed a trend to association with breast cancer risk in BRCA1 carriers ages <50 years.
|
19366906 |
2009 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Testing for the CYP19 rs4646 SNP as a predictive tool for breast cancer patients on antiaromatase therapy deserves prospective evaluation.
|
18245543 |
2008 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
In a case-control study nested within a breast self-examination trial conducted in China, we examined whether CYP19A1 polymorphisms (rs1870049, rs1004982, rs28566535, rs936306, rs11636639, rs767199, rs4775936, rs11575899, rs10046, and rs4646) were associated with risk of breast cancer and fibrocystic breast conditions.
|
19064562 |
2008 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
SNPs rs10046 and rs4646 may influence the HER2 status of breast cancer tumors, and rs10046 genotypes are associated with an altered DFS.
|
18049890 |
2008 |
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggested that the IL-16 rs859, CYP19A1 rs4646, and BACH1 rs372883 polymorphisms have potential roles in the genetic susceptibility to IgAN in Chinese Han population.
|
31067541 |
2019 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of this study indicate that the rs2236722 and rs4646 of the CYP19A1 gene are associated with CAD and circulating sex hormone levels in the Xinjiang population of China.
|
29228596 |
2017 |
|
Prognostic Stage III Breast Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping for CYP19 rs4646 variants was performed on 406 Chinese women with stage I-II and operable stage III breast cancer.
|
25793413 |
2015 |
|
Anatomic Stage III Breast Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping for CYP19 rs4646 variants was performed on 406 Chinese women with stage I-II and operable stage III breast cancer.
|
25793413 |
2015 |
|
Breast cancer stage III
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping for CYP19 rs4646 variants was performed on 406 Chinese women with stage I-II and operable stage III breast cancer.
|
25793413 |
2015 |
|
Stage III Breast Cancer AJCC v6
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping for CYP19 rs4646 variants was performed on 406 Chinese women with stage I-II and operable stage III breast cancer.
|
25793413 |
2015 |