Glaucoma
|
|
0.810 |
GeneticVariation
|
BEFREE |
In this study, we determined association of the most significantly associated single nucleotide polymorphism (SNP) rs4656461, at 1q24 near the TMCO1 gene, with the clinical parameters related to glaucoma risk and diagnosis, and determined ocular expression and subcellular localization of the human TMCO1 protein to understand the mechanism of its involvement in POAG.
|
22714896 |
2012 |
Glaucoma
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1.
|
21532571 |
2011 |
Glaucoma
|
|
0.810 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1.
|
21532571 |
2011 |
Glaucoma, Open-Angle
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.
|
25173105 |
2014 |
Glaucoma, Open-Angle
|
|
0.710 |
GeneticVariation
|
BEFREE |
We replicated these associations in an independent cohort of cases with advanced OAG (rs4656461 P = 0.010; rs4977756 P = 0.042) and two additional cohorts of less severe OAG (rs4656461 combined discovery and replication P = 6.00 × 10(-14), OR = 1.51, 95% CI 1.35-1.68; rs4977756 combined P = 1.35 × 10(-14), OR = 1.39, 95% CI 1.28-1.51).
|
21532571 |
2011 |
Tonometry
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association analyses identify new loci influencing intraocular pressure.
|
29617998 |
2018 |
Physiologic Intraocular Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study and meta-analysis of intraocular pressure.
|
24002674 |
2014 |
Glaucoma, Primary Open Angle
|
|
0.030 |
GeneticVariation
|
BEFREE |
The SNPs rs4656461 and rs7555523 at TMCO1, rs523096 and rs2157719 at CDKN2B-AS1, as well as rs33912345 and rs10483727 at SIX1/SIX6 showed statistically significant association with POAG.
|
25711633 |
2015 |
Glaucoma, Primary Open Angle
|
|
0.030 |
GeneticVariation
|
BEFREE |
This study demonstrates that the TMCO1 rs4656461 variant is associated with POAG, PACG and PEXG in the Pakistani population.
|
25489222 |
2014 |
Glaucoma, Primary Open Angle
|
|
0.030 |
GeneticVariation
|
BEFREE |
Association of SNP rs4656461 with five clinical parameters was assessed in 1420 POAG cases using linear regression.
|
22714896 |
2012 |
Primary angle-closure glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates that the TMCO1 rs4656461 variant is associated with POAG, PACG and PEXG in the Pakistani population.
|
25489222 |
2014 |
Angle Closure Glaucoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates that the TMCO1 rs4656461 variant is associated with POAG, PACG and PEXG in the Pakistani population.
|
25489222 |
2014 |