rs4656461, None

N. diseases: 7
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Glaucoma
CUI: C0017601
Disease: Glaucoma
0.810 GeneticVariation BEFREE In this study, we determined association of the most significantly associated single nucleotide polymorphism (SNP) rs4656461, at 1q24 near the TMCO1 gene, with the clinical parameters related to glaucoma risk and diagnosis, and determined ocular expression and subcellular localization of the human TMCO1 protein to understand the mechanism of its involvement in POAG. 22714896 2012
Glaucoma
CUI: C0017601
Disease: Glaucoma
0.810 GeneticVariation GWASCAT Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. 21532571 2011
Glaucoma
CUI: C0017601
Disease: Glaucoma
0.810 GeneticVariation GWASDB Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. 21532571 2011
Glaucoma, Open-Angle
CUI: C0017612
Disease: Glaucoma, Open-Angle
0.710 GeneticVariation GWASCAT Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. 25173105 2014
Glaucoma, Open-Angle
CUI: C0017612
Disease: Glaucoma, Open-Angle
0.710 GeneticVariation BEFREE We replicated these associations in an independent cohort of cases with advanced OAG (rs4656461 P = 0.010; rs4977756 P = 0.042) and two additional cohorts of less severe OAG (rs4656461 combined discovery and replication P = 6.00 × 10(-14), OR = 1.51, 95% CI 1.35-1.68; rs4977756 combined P = 1.35 × 10(-14), OR = 1.39, 95% CI 1.28-1.51). 21532571 2011
Tonometry
CUI: C0040420
Disease: Tonometry
0.700 GeneticVariation GWASCAT Genome-wide association analyses identify new loci influencing intraocular pressure. 29617998 2018
Physiologic Intraocular Pressure
CUI: C0021888
Disease: Physiologic Intraocular Pressure
0.700 GeneticVariation GWASDB Genome-wide association study and meta-analysis of intraocular pressure. 24002674 2014
Glaucoma, Primary Open Angle
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
0.030 GeneticVariation BEFREE The SNPs rs4656461 and rs7555523 at TMCO1, rs523096 and rs2157719 at CDKN2B-AS1, as well as rs33912345 and rs10483727 at SIX1/SIX6 showed statistically significant association with POAG. 25711633 2015
Glaucoma, Primary Open Angle
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
0.030 GeneticVariation BEFREE This study demonstrates that the TMCO1 rs4656461 variant is associated with POAG, PACG and PEXG in the Pakistani population. 25489222 2014
Glaucoma, Primary Open Angle
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
0.030 GeneticVariation BEFREE Association of SNP rs4656461 with five clinical parameters was assessed in 1420 POAG cases using linear regression. 22714896 2012
Primary angle-closure glaucoma
CUI: C0017606
Disease: Primary angle-closure glaucoma
0.010 GeneticVariation BEFREE This study demonstrates that the TMCO1 rs4656461 variant is associated with POAG, PACG and PEXG in the Pakistani population. 25489222 2014
Angle Closure Glaucoma
CUI: C0017605
Disease: Angle Closure Glaucoma
0.010 GeneticVariation BEFREE This study demonstrates that the TMCO1 rs4656461 variant is associated with POAG, PACG and PEXG in the Pakistani population. 25489222 2014