Mental disorders
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0.100 |
GeneticVariation
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BEFREE |
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.
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16542182 |
2006 |
Mental disorders
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|
0.100 |
GeneticVariation
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BEFREE |
To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene.
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21231925 |
2011 |
Mental disorders
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0.100 |
GeneticVariation
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BEFREE |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders.
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24708432 |
2014 |
Mental disorders
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0.100 |
GeneticVariation
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BEFREE |
The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele.
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18384078 |
2008 |
Mental disorders
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0.100 |
GeneticVariation
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BEFREE |
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure.
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22138198 |
2012 |
Mental disorders
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0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior.
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24389396 |
2014 |
Mental disorders
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0.100 |
GeneticVariation
|
BEFREE |
Role of the COMT gene Val158Met polymorphism in mental disorders: a review.
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17419009 |
2007 |
Mental disorders
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0.100 |
GeneticVariation
|
BEFREE |
Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts.
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27203226 |
2016 |
Mental disorders
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0.100 |
GeneticVariation
|
BEFREE |
Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.
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28608575 |
2018 |
Mental disorders
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|
0.100 |
GeneticVariation
|
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
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23799032 |
2013 |
Mental disorders
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0.100 |
GeneticVariation
|
BEFREE |
It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior.
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21486391 |
2011 |