rs4680, COMT;MIR4761

N. diseases: 249
Disease: Carcinoma of lung ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.040 GeneticVariation BEFREE RESULTS The results obtained from this study demonstrated that XRCC1-77TC + CC, XRCC1 399Gln/Gln, COMT 186CT + TT, COMT 158Val/Met genotypes, type of occupation, cooking-oil fumes, and soot exposures were all independent risk factors involved with the occurrence of lung cancer among non-smoking women. 30109864 2018
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.040 GeneticVariation BEFREE Our findings indicate that CYP2E1 rs2031920 and COMT rs4680 are not major contributors to lung cancer risk in our Japanese population. 27644662 2016
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.040 GeneticVariation BEFREE Five publications, including six individual studies with a total of 4,043 subjects (1,796 cases and 2,247 controls) regarding the association of COMT Val158Met polymorphism with lung cancer susceptibility were included in this meta-analysis. 25280560 2014
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.040 GeneticVariation BEFREE The COMT rs4680 A allele was positively associated with lung cancer in never smokers (for G/A or A/A vs. G/G, OR = 1.46, 95% CI: 1.12, 1.90) but not in ever smokers. 22331461 2012