|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
BEFREE |
These results suggest that the CD40 SNPs rs1883832 and rs4810485 are not RA susceptibility markers in the western Mexican population.
|
27813548 |
2016 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
BEFREE |
Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
|
25908480 |
2015 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
GWASDB |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
BEFREE |
Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.
|
20498205 |
2010 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
BEFREE |
The TT and CC/CG genotypes of 2 single-nucleotide polymorphisms, rs4810485 (CD40) and rs42041 (CDK6), respectively, were associated with a higher rate of joint destruction in ACPA-positive RA patients (P=0.003 and P=0.012, respectively), with rs4810485 being significant after Bonferroni correction for multiple testing.
|
19644859 |
2009 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|
18794853 |
2008 |
|
Rheumatoid Arthritis
|
|
0.840 |
GeneticVariation
|
GWASDB |
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|
18794853 |
2008 |
|
Multiple Sclerosis
|
|
0.810 |
GeneticVariation
|
BEFREE |
Using flow cytometry we measured surface expression of CD40 and CD86 in B cells from 68 patients and 162 healthy controls that were genotyped for the multiple sclerosis associated single nucleotide polymorphisms (SNPs) rs4810485, which maps within the CD40 gene, and rs9282641, which maps within the CD86 gene.
|
29361022 |
2018 |
|
Multiple Sclerosis
|
|
0.810 |
GeneticVariation
|
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
Multiple Sclerosis
|
|
0.810 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.770 |
GeneticVariation
|
BEFREE |
Fourteen studies were included.Ethnicity-specific meta-analysis indicated a significant association between the T allele of <i>CD40</i> rs4810485 polymorphism and systemic lupus erythematosus in Europeans (odds ratio = 0.715, 95% confidence interval = 0.641-0.832, <i>p</i> < 0.001) and a trend toward an association between the T allele and systemic lupus erythematosus in Asians (odds ratio = 1.255, 95% confidence interval = 0.978-1.810, <i>p</i> = 0.074).
|
31570051 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.770 |
GeneticVariation
|
BEFREE |
This study aimed to evaluate the association of CD40 polymorphisms (-1 C > T, rs1883832 and 6,048 G > T, rs4810485) with SLE susceptibility, as well as with mRNA expression and soluble CD40 (sCD40) levels.
|
31642196 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.770 |
GeneticVariation
|
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.770 |
GeneticVariation
|
BEFREE |
Our results support an important association of rs4810</span>485 in CD40 gene and rs763361 in CD226 gene polymorphism, combined effect of rs4810485 and rs763361 with increased risk of SLE.
|
27722794 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.770 |
GeneticVariation
|
BEFREE |
We analyzed three single nucleotide polymorphisms of CD40 gene rs1883832C/T, rs1569723A/C and rs4810485G/T in 205 patients with SLE and 220 age-and sex-matched controls.
|
26474561 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.770 |
GeneticVariation
|
BEFREE |
Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
|
25908480 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.770 |
GeneticVariation
|
BEFREE |
There is one study on the association of the CD40 G > T (rs4810485) single nucleotide polymorphism (SNP) as a risk factor of systemic lupus erythematosus (SLE).
|
23257401 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.770 |
GeneticVariation
|
BEFREE |
The rs4810485 minor allele T is under-represented in SLE and correlates with reduced CD40 expression in peripheral blood monocytes and B cells, with potential implications for the regulation of aberrant immune responses in the disease.
|
21914625 |
2011 |
|
Autoimmune Diseases
|
|
0.710 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression at the mRNA and protein level.
|
27813548 |
2016 |
|
Autoimmune Diseases
|
|
0.710 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Immune System Diseases
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Behcet Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Associations of rs4810485 and rs1883832 polymorphisms of CD40 gene with susceptibility and clinical findings of Behçet's disease.
|
25373542 |
2015 |