|
Dyskinetic syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, clinical-pharmacogenetic model for prediction of time to occurrence of dyskinesia included female sex (HR = 1.07), age at diagnosis (HR = 0.97), tremor-predominant Parkinson's disease (HR = 0.88), beta-blockers (HR = 0.95), alcohol consumption (HR = 0.99), time from diagnosis to initiation of levodopa treatment (HR = 1.15), <i>CAT</i> rs1001179 (HR = 1.27), <i>SOD2</i> rs4880 (HR = 0.95), <i>NOS1</i> rs2293054 (HR = 0.99), <i>COMT</i> rs165815 (HR = 0.92), and <i>SLC22A1</i> rs628031 (HR = 0.80).
|
31156712 |
2019 |
|
Seizures
|
|
0.010 |
GeneticVariation
|
BEFREE |
Involvement of MnSOD Ala16Val polymorphism in epilepsy: A relationship with seizure type, inflammation, and metabolic syndrome.
|
31212050 |
2019 |
|
Hypotension, Orthostatic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR = 1.75; 95%CI = 1.00-3.06, p = 0.048), SOD2 rs4880 T allele and nausea/vomiting (OR = 0.49, 95%CI = 0.25-0.94; p = 0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR = 0.57, 95%CI = 0.32-1.00, p = 0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR = 2.59; 95%CI = 1.09-6.19; p = 0.032).
|
30813952 |
2019 |
|
Disruptive, Impulse Control, and Conduct Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR = 1.75; 95%CI = 1.00-3.06, p = 0.048), SOD2 rs4880 T allele and nausea/vomiting (OR = 0.49, 95%CI = 0.25-0.94; p = 0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR = 0.57, 95%CI = 0.32-1.00, p = 0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR = 2.59; 95%CI = 1.09-6.19; p = 0.032).
|
30813952 |
2019 |
|
Sleep attack
|
|
0.010 |
GeneticVariation
|
BEFREE |
Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR = 1.75; 95%CI = 1.00-3.06, p = 0.048), SOD2 rs4880 T allele and nausea/vomiting (OR = 0.49, 95%CI = 0.25-0.94; p = 0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR = 0.57, 95%CI = 0.32-1.00, p = 0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR = 2.59; 95%CI = 1.09-6.19; p = 0.032).
|
30813952 |
2019 |
|
Nausea and vomiting
|
|
0.010 |
GeneticVariation
|
BEFREE |
Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR = 1.75; 95%CI = 1.00-3.06, p = 0.048), SOD2 rs4880 T allele and nausea/vomiting (OR = 0.49, 95%CI = 0.25-0.94; p = 0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR = 0.57, 95%CI = 0.32-1.00, p = 0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR = 2.59; 95%CI = 1.09-6.19; p = 0.032).
|
30813952 |
2019 |
|
Excessive daytime sleepiness
|
|
0.010 |
GeneticVariation
|
BEFREE |
Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR = 1.75; 95%CI = 1.00-3.06, p = 0.048), SOD2 rs4880 T allele and nausea/vomiting (OR = 0.49, 95%CI = 0.25-0.94; p = 0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR = 0.57, 95%CI = 0.32-1.00, p = 0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR = 2.59; 95%CI = 1.09-6.19; p = 0.032).
|
30813952 |
2019 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, we investigated the relationship between MnSOD Ala16Val SNP with epilepsy and its influence on MetS, inflammation, apoptosis and DNA damage parameters.
|
31212050 |
2019 |
|
Anemia, Sickle Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the <i>SOD2</i> Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia.
|
29531649 |
2018 |
|
Depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the T/T genotype of the c.47T>C polymorphism was linked with an increased risk of depression.
|
29331597 |
2018 |
|
Vaso-Occlusive Crisis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the <i>SOD2</i> Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia.
|
29531649 |
2018 |
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association between IGAN and the redox related variant allele rs4880(C) might indicate a new susceptibility locus for IGAN, but this needs verification.
|
29655960 |
2018 |
|
Depressed mood
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the T/T genotype of the c.47T>C polymorphism was linked with an increased risk of depression.
|
29331597 |
2018 |
|
Mental Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the T/T genotype of the c.47T>C polymorphism was linked with an increased risk of depression.
|
29331597 |
2018 |
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls.
|
28052094 |
2017 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we sought to determine a potential association between the variant rs4880 in SOD2 gene, a key mitochondrial enzyme that protects cells against ROS, and hepatotoxicity during asparaginase-based therapy in 224 patients enrolled on CALGB-10102, a treatment trial for adults with ALL.
|
27019981 |
2017 |
|
Diabetic dyslipidaemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), and MNSOD (rs4880) polymorphisms play an important role in basic molecular metabolism in diabetic dyslipidemia.
|
28315561 |
2017 |
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we sought to determine a potential association between the variant rs4880 in SOD2 gene, a key mitochondrial enzyme that protects cells against ROS, and hepatotoxicity during asparaginase-based therapy in 224 patients enrolled on CALGB-10102, a treatment trial for adults with ALL.
|
27019981 |
2017 |
|
Idiopathic pulmonary arterial hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
There is significant association between SOD rs4880 polymorphism and the PAH susceptibility, and this polymorphism influenced PAH susceptibility by altering the expression of SOD2.
|
28272301 |
2017 |
|
Vascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ALA16VAL-MnSOD gene single nucleotide polymorphism (SNP) has shown to modulate risk factors of several metabolic and vascular diseases, such as blood glucose (GLU) and lipid levels.
|
28552711 |
2017 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, we propose that the Ala16Val-MnSOD SNPs may contribute to hypercholesterolemia and higher GLU levels, increasing the risk to neurovascular events that may lead to stroke.
|
28552711 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia.
|
27019981 |
2017 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although a few studies have been conducted, there have been no reports on catalase (CAT C262T), manganese superoxide dismutase (MnSOD Ala16Val) and glutathione peroxidase 1 (GPX1 Pro198Leu) gene polymorphisms and IS risk.
|
28198160 |
2017 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we sought to determine a potential association between the variant rs4880 in SOD2 gene, a key mitochondrial enzyme that protects cells against ROS, and hepatotoxicity during asparaginase-based therapy in 224 patients enrolled on CALGB-10102, a treatment trial for adults with ALL.
|
27019981 |
2017 |
|
Myeloproliferative disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
To analyze the relationship between six polymorphisms in genes related to oxidative stress, namely CAT-262 C>T, MnSOD Ala16Val, GPX1 Pro198Leu, GSTM1 and GSTT1 null genotypes, and GSTP1 Ile105Val, and the occurrence of BCR-ABL negative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, and primary myelofibrosis).
|
27077777 |
2016 |