|
AA amyloidosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neither myeloid cell TLR-2 and TLR-4 expressions nor TLR-2 Arg753Gln, TLR-4 Asp299Gly, and Thr399Ile polymorphisms seem to affect the development of secondary amyloidosis in FMF patients in our study population.
|
20714796 |
2011 |
|
Active tuberculosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TLR4 ASP299GLY polymorphism is a risk factor for active tuberculosis in Caucasian HIV-infected patients.
|
20226000 |
2010 |
|
Active tuberculosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.
|
17545720 |
2007 |
|
Acute bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found no association between TLR4 polymorphisms (Asp299Gly and Thr399Ile) and the development of acute bronchiolitis.
|
25572736 |
2015 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results, which must be confirmed by a prospective longitudinal study, provide evidence of an association between the Asp299Gly polymorphism of the human TLR4 receptor and acute coronary syndromes.
|
14563652 |
2003 |
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed 154 patients after allogeneic HSCT for acute leukemia for TLR4 gene variants 1063A/G (D299G) and 1363C/T (T399I) with their respective donors, and correlated the results with the incidence of invasive aspergillosis (IA) infection after transplant.
|
23890253 |
2013 |
|
Acute Motor Axonal Neuropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Besides Asp299Gly, AMAN subtype is also associated with Thr399Ile polymorphism.
|
19913922 |
2010 |
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recently, the common Asp299Gly polymorphism of the Toll-like receptor 4 (TLR-4) was found to be associated with a reduced incidence of acute myocardial infarction and carotid atherosclerosis.
|
17587646 |
2007 |
|
Acute pancreatitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 Asp299Gly polymorphism is associated with the infection of pancreatic necrosis in AP.
|
17414051 |
2007 |
|
Acute pancreatitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In view of the inflammatory nature of acute pancreatitis, we aimed to determine the predictive value of two point mutations in the promoter region at position -550 (H/L variants) and -221 (X/Y variants) of the MBL2 gene, and the Asp299Gly and 119C>A polymorphisms of the TLR4 gene on the occurrence of severe acute pancreatitis (SAP).
|
18288881 |
2008 |
|
Acute pancreatitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.
|
24914392 |
2014 |
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
One hundred and eleven patients with aggressive periodontitis and 80 periodontally healthy controls were genotyped for four functional variants in the TLR4 gene (c.896A>G and c.1196C>T) and in the IL-18 promoter (c.-368G>C and c.-838C>A).
|
18983635 |
2008 |
|
Acute periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP).
|
26079505 |
2015 |
|
Acute pyelonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with APN were significantly more likely to have AA genotype of the ICAM-1 rs5498 (1462 A/G) polymorphism (p = 0.04) than children with lower UTIs and the TLR-4 Asp299Gly GG genotype (p = 0.002) and G allele (p = 0.006) than healthy controls.
|
29028278 |
2018 |
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Human colon adenocarcinomas from patients with TLR4-D299G were more frequently of an advanced stage (International Union Against Cancer [UICC] ≥III, 70% vs 46%; P = .0142) with metastasis (UICC IV, 42% vs 19%; P = .0065) than those with wild-type TLR4.
|
21920464 |
2011 |
|
Adrenoleukodystrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association between ALD and the presence of the Asp299Gly and Thr399Ile polymorphisms in the TLR-4 gene could be documented in our patients.
|
23009036 |
2013 |
|
Adult Hodgkin Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the TLR4 Asp299Gly variant was positively associated with the risk of mucosa-associated lymphoid tissue lymphoma (OR=2.76, 95% CI=1.12-6.81) and HL (OR=1.80, 95% CI=0.99-3.26).
|
16971956 |
2006 |
|
Age related macular degeneration
|
|
0.040 |
GeneticVariation
|
BEFREE |
Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined.
|
19628747 |
2009 |
|
Age related macular degeneration
|
|
0.040 |
GeneticVariation
|
BEFREE |
Although an intronic SNP in TLR4 was associated marginally with AMD (P = 0.03), it was not possible to replicate a previous association with the rare coding SNP D299G in this gene (P = 0.6).
|
18385087 |
2008 |
|
Age related macular degeneration
|
|
0.040 |
GeneticVariation
|
BEFREE |
TLR4-D299G showed an additive effect on AMD risk (odds ratio=4.13, P=0.002) with allelic variants of apolipoprotein E (APOE) and ATP-binding cassette transporter-1 (ABCA1), two genes involved in cholesterol efflux.
|
15829498 |
2005 |
|
Age related macular degeneration
|
|
0.040 |
GeneticVariation
|
BEFREE |
Analysis of single nucleotide polymorphisms (SNPs) in the TLR4 gene did not show a significant association between D299G or T399I and AMD, nor did haplotypes containing these variants.
|
18172114 |
2008 |
|
Aggressive Periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
One hundred and eleven patients with aggressive periodontitis and 80 periodontally healthy controls were genotyped for four functional variants in the TLR4 gene (c.896A>G and c.1196C>T) and in the IL-18 promoter (c.-368G>C and c.-838C>A).
|
18983635 |
2008 |
|
Aggressive Periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP).
|
26079505 |
2015 |
|
Allergic asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR4 Asp299Gly polymorphisms were associated with asthma and with decreased odds of nonatopic asthma compared with atopic asthma in the adult population in Crimea.
|
31530336 |
2020 |
|
Allergic asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TLR4 (Asp299Gly) polymorphism and independently with asthma, especially atopic asthma.
|
15356557 |
2004 |