|
Hepatitis C
|
|
0.050 |
GeneticVariation
|
BEFREE |
<i>In silico</i> analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.<b>Conclusion:</b> We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
|
30765614 |
2019 |
|
Arteriosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
1400 participants (mean age: 63 years, 31% female) in the Southampton Atherosclerosis Study were genotyped for the TLR4 Asp299Gly polymorphism using the tetra-primer PCR method.
|
12957699 |
2003 |
|
Atherosclerosis
|
|
0.090 |
GeneticVariation
|
BEFREE |
1400 participants (mean age: 63 years, 31% female) in the Southampton Atherosclerosis Study were genotyped for the TLR4 Asp299Gly polymorphism using the tetra-primer PCR method.
|
12957699 |
2003 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
90 patients with CD and 80 healthy individuals are genotyped for the Asp299Gly and Thr399Ile polymorphisms by restriction fragment length polymorphism analysis.
|
19664207 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
|
14693986 |
2004 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
D299G and T399I were related to CD only in patients carrying NOD2 variants (NOD2+/TLR4+ haplotype) (p=0.036; OR=1.924), increasing the risk to develop CD when 1007insC and TLR4 variants were both present (OR=4.886).
|
27290609 |
2016 |
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to explore the role of IL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), and TLR4_896A/G (rs4986790) polymorphisms in the susceptibility to colorectal cancer (n = 244), gastric carcinoma (n = 72), and ovarian cancer (n = 85).
|
24446182 |
2014 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.050 |
GeneticVariation
|
BEFREE |
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to explore the role of IL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), and TLR4_896A/G (rs4986790) polymorphisms in the susceptibility to colorectal cancer (n = 244), gastric carcinoma (n = 72), and ovarian cancer (n = 85).
|
24446182 |
2014 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A coding variant in the TLR4 receptor (rs4986790), previously associated with longevity and Alzheimer's disease (AD) risk reduction, was examined in a population isolate (Québec Founder Population [QFP]) and in presymptomatic individuals with a parental history of AD (Pre-Symptomatic Evaluation of Novel or Experimental Treatment for Alzheimer's Disease [PREVENT-AD]).
|
31175027 |
2019 |
|
Hepatitis C
|
|
0.050 |
GeneticVariation
|
BEFREE |
A historical cohort of 92 liver transplant patients with chronic HCV were screened for TLR2 Arg753Gln and TLR4 Asp299Gly and Thr399Ile polymorphisms.
|
17713436 |
2007 |
|
Giant Cell Arteritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
A meta-analysis, comprising 577 GCA patients and 1153 controls, did not confirm an association between GCA and rs4986790 (OR 1.29, 95% CI 0.86, 1.92, p=0.22).
|
24447403 |
2014 |
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A non-significant suggestion of effect modification was observed by rs4986790 carrier status on the association between T. vaginalis serostatus and prostate cancer risk (p interaction = 0.07).
|
23179660 |
2013 |
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
A non-significant suggestion of effect modification was observed by rs4986790 carrier status on the association between T. vaginalis serostatus and prostate cancer risk (p interaction = 0.07).
|
23179660 |
2013 |
|
Endotoxin Hyporesponsiveness
|
|
0.020 |
GeneticVariation
|
BEFREE |
A non-synonymous variant in the extracellular domain of TLR4 (G299D) has been shown to interrupt TLR4-mediated signalling, resulting in endotoxin hyporesponsiveness.
|
18180278 |
2008 |
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A phenotypic correlation of Asp299Gly-AG genotype with arthritis in UC patients was detected (P = 0.003).
|
29055077 |
2017 |
|
Coronary heart disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
A polymorphism of the TLR4 gene, Asp299Gly, is associated with an increased risk for coronary heart diseases in Caucasian populations.
|
15910856 |
2005 |
|
Cystic Echinocccosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A relative genetic variability of TLR4 Asp299Gly was found in RH patients (haplotype diversity: 0.700) compared to AH patients and healthy controls (Hd: 0.000).
|
29602972 |
2018 |
|
Echinococcosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A relative genetic variability of TLR4 Asp299Gly was found in RH patients (haplotype diversity: 0.700) compared to AH patients and healthy controls (Hd: 0.000).
|
29602972 |
2018 |
|
Bronchopulmonary Aspergillosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003).
|
18275280 |
2008 |
|
Pulmonary Aspergillosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003).
|
18275280 |
2008 |
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A TDT on 318 IBD trios demonstrated preferential transmission of the TLR4 Asp299Gly polymorphism from heterozygous parents to affected children (T/U: 68/34, p = 0.01).
|
15194649 |
2004 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
|
0.060 |
GeneticVariation
|
BEFREE |
A Toll-like receptor-4 (TLR-4) Asp299Gly and Thr399Ileu substitution reduces responsiveness to Helicobacter pylori (H. pylori) lipopolysaccharide.
|
18082569 |
2007 |
|
Epilepsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
A total of 140 patients with NCC (82 symptomatic [ie, with active epilepsy] and 58 asymptomatic) and 150 healthy control subjects were examined for TLR4 Asp299Gly and Thr399Ile polymorphisms by means of polymerase chain reaction and restriction fragment-length polymorphism.
|
20807077 |
2010 |