|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
The host response to H. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses.Our aim was to investigate whether the presence of the TLR4 Asp299Gly, TLR4 Thr399Ile and IL-8-251 A/T polymorphisms had any influence in the development of distal GC in a Mexican population.
|
17462092 |
2007 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
However, meta-analysis demonstrated significantly higher frequencies of both Asp299Gly and Thr399Ile SNPs in IBD and CD and for 399Ileu carriage in UC patients.
|
25492126 |
2014 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
The Asp299Gly and Thr399Ile variants do not show an association with CD, UC, or IBD as a group, indicating that these polymorphisms are likely not the causal ones.
|
15905704 |
2005 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05).
|
18680223 |
2008 |
|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results demonstrated that TLR-4 Thr399Ile polymorphism is linked with an increased susceptibility to gastric cancer.
|
18826495 |
2008 |
|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms were reported to be a risk factor of gastric carcinoma or its precursors in Caucasian and Indian population, but these polymorphisms are absent in Japanese.
|
19191896 |
2009 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
The TLR4-Thr399Ile variant was strongly associated with susceptibility to IBD, whereas TLR4-Asp299Gly seems to play a role in the clinical expression of UC.
|
29055077 |
2017 |
|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis.
|
18755634 |
2008 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
TLR4 Thr399Ile may be associated with IBD susceptibility in Caucasians only.
|
26023918 |
2015 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.
|
18680223 |
2008 |
|
Inflammatory Bowel Diseases
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease.
|
18034244 |
2008 |
|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.
|
22468087 |
2012 |
|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
It seems to be that Asp299Gly and Thr399Ile are related to increased risk of precancerous gastric lesions, and, possibly, gastric cancer.
|
21081146 |
2011 |
|
Septicemia
|
|
0.070 |
GeneticVariation
|
BEFREE |
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis.
|
25454804 |
2015 |
|
Septicemia
|
|
0.070 |
GeneticVariation
|
BEFREE |
In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis.
|
21968286 |
2012 |
|
Sepsis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
|
Septicemia
|
|
0.070 |
GeneticVariation
|
BEFREE |
We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models.
|
27958344 |
2016 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
|
0.070 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and Thr399Ile and CD14, C-159T and C-550T in the development of RSV bronchiolitis.
|
25572736 |
2015 |
|
Septicemia
|
|
0.070 |
GeneticVariation
|
BEFREE |
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease.
|
18034244 |
2008 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
|
0.070 |
GeneticVariation
|
BEFREE |
TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus.
|
20711470 |
2010 |
|
Sepsis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis.
|
25454804 |
2015 |
|
Septicemia
|
|
0.070 |
GeneticVariation
|
BEFREE |
The odds ratio for the association of Asp299Gly polymorphism with sepsis risk was 1.22 (95% CI: 0.90-1.65, P=0.21), and the association of Thr399Ile</span> polymorphism was 1.16 (95%CI: 0.70-1.91, P=0.57).
|
22537674 |
2012 |
|
Malignant neoplasm of stomach
|
|
0.070 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
|
Malignant neoplasm of stomach
|
|
0.070 |
GeneticVariation
|
BEFREE |
The host response to H. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses.Our aim was to investigate whether the presence of the TLR4 Asp299Gly, TLR4 Thr399Ile and IL-8-251 A/T polymorphisms had any influence in the development of distal GC in a Mexican population.
|
17462092 |
2007 |
|
Septicemia
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis.
|
12404174 |
2002 |