|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
The European -13,910*T (rs4988235) was the only LP causative variant found, showing strong association (99.6%) with LP phenotype.
|
30264486 |
2019 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
Genotyping of LCT-13910 C/T (rs4988235) was performed to assess primary lactase persistence.
|
30721917 |
2019 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
One single nucleotide polymorphism (SNP ID: rs4988235) is often used as a predictor for dairy intake, since it is responsible for LP in people in European descent, and can occur in other ethnic groups.
|
31405126 |
2019 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
Other dietary intakes associated with rs4988235 included fruits (β -7.0 g/day, 95% CI -12.4 to -1.7 per additional LP allele), nonalcoholic beverages (β -18.0 g/day, 95% CI -34.4 to -1.6), and wine (β -4.8 g/day, 95% CI -9.1 to -0.6).
|
30728219 |
2019 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
We investigated the association between milk intake, LCT-13910 C/T (rs4988235), which is associated with lactase persistence (TT/TC) in Northern Europeans, and hip fractures in three Danish prospective studies (N = 97 811, age ≥20 years).
|
29537719 |
2018 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
<i>LCT-13910 C/T</i> (rs4988235) is associated with lactase persistence (<i>TT/TC</i>) in Northern Europeans.
|
30096803 |
2018 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
<b>Objective</b> To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal.<b>Design</b> Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable.<b>Setting</b> CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium.<b>Participants</b> Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis.<b>Main outcome measures</b> The instrumental variable estimation was conducted using the ratio of coefficients approach.
|
28302601 |
2017 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
Instrumental variable analysis based on a genetic variant endowing lactase persistence (rs4988235 (MCM6)) was used to obtain estimates for osteoporosis (GEFOS), IHD (CARDIoGRAMplusC4D), T2D (DIAGRAM), adiposity (GIANT), lipids (GLGC) and glycaemic traits (MAGIC).
|
28225053 |
2017 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about 14 kb upstream of the lactase gene [-13910*T (rs4988235), -13907*G (rs41525747), -13915*G (rs41380347), -14009*G (rs869051967) and -14010*C (rs145946881)].
|
29063188 |
2017 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
We investigated the association of milk intake with obesity and BP using genetically-defined lactase persistence (LP) based on the rs4988235 polymorphism in a Mendelian randomization design in the 1982 Pelotas (Southern Brazil) Birth Cohort.
|
27170764 |
2016 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
Second, we confirmed the association between the rs4988235 genetic variant LCT-13910 C/T, associated with lactase persistence/non-persistence, and milk intake.
|
26085675 |
2015 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
In 97,811 individuals from the Danish general population, we examined the risk of incident type 2 diabetes and of overweight-obesity by milk intake observationally and by LCT-13910 C/T genotype [polymorphism (rs4988235) upstream from the lactase (LCT) gene], where TT and TC genotypes are associated with lactase persistence and CC with nonpersistence.
|
26156736 |
2015 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
The T allele of a functional polymorphism (rs4988235: LCT-13910 C>T), close to the lactase gene, correlates with lactase persistence (LP) in adults.
|
23647908 |
2013 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
The -13910C>T polymorphism (rs4988235) upstream from the lactase (LCT) gene, strongly associated with lactase persistence (LP) in Europeans, is emerging as a new candidate for obesity.
|
21193851 |
2011 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis by pooling the beta-coefficient estimates of the relationship between rs4988235 and BMI from the nine studies and found that the carriers of the allele responsible for LP among Europeans showed higher BMI (P = 7.9 x 10(-5)).
|
20015952 |
2010 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
Among controls, consumption of milk was associated with the lactase persistence genotype at rs4988235 (OR, 2.39; 95% CI, 1.81-3.15; P=6.9x10(-10)); however, the same genotype was not associated with RCC (OR, 1.01; 95% CI, 0.83-1.22; P=0.9).
|
20447925 |
2010 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
BEFREE |
We genotyped the C/T(-13910) variant (rs4988235) that constitutes the putatively causal allele for lactase persistence (T allele representing persistence) in a general population sample of 3344 women aged 60-79 years from 23 towns across Britain.
|
18797476 |
2009 |
|
LACTASE PERSISTENCE
|
|
0.800 |
GeneticVariation
|
CLINVAR |
|
|
|
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
|
30108127 |
2018 |
|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
|
26426971 |
2015 |
|
Hip circumference
|
|
0.700 |
GeneticVariation
|
GWASCAT |
New genetic loci link adipose and insulin biology to body fat distribution.
|
25673412 |
2015 |
|
Obesity
|
|
0.040 |
GeneticVariation
|
BEFREE |
Several studies reported associations of the lactase gene (LCT) polymorphism -13910C>T (rs4988235) with obesity-related variables and obesity in adults.
|
27577176 |
2017 |
|
Obesity
|
|
0.040 |
GeneticVariation
|
BEFREE |
We investigated the association of milk intake with obesity and BP using genetically-defined lactase persistence (LP) based on the rs4988235 polymorphism in a Mendelian randomization design in the 1982 Pelotas (Southern Brazil) Birth Cohort.
|
27170764 |
2016 |