|
Serum total cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |
|
Serum total cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.
|
23236364 |
2012 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.
|
23236364 |
2012 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.
|
22629316 |
2012 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.
|
23236364 |
2012 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.
|
22629316 |
2012 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
In CAD patients, the AG genotype of PSCK9 rs505151 is associated with diabetes and a positive family history of CAD.
|
30947598 |
2020 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
No significant association between the PCSK9 E670G polymorphism and serum PCSK9 levels was observed in the CAD group and the controls.
|
30205809 |
2018 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
The present meta-analysis concluded that PCSK9 E670G polymorphism was associated with CAD risk and lipid levels.
|
26576960 |
2015 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
The E670G polymorphism of the PCSK9 gene is mainly associated with a increased risk and severity of CAD and IS in Tunisian cohort.
|
24599757 |
2014 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
These results indicate that the E670G polymorphism of the PCSK9 gene modulates plasma LDL-C levels, but that it is not a risk variant for CAD in ethnic Chinese in Taiwan.
|
19191720 |
2009 |
|
Coronary Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis.
|
26576960 |
2015 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis.
|
26576960 |
2015 |
|
Coronary Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Effect of E670G Polymorphism in PCSK9 Gene on the Risk and Severity of Coronary Heart Disease and Ischemic Stroke in a Tunisian Cohort.
|
24599757 |
2014 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Effect of E670G Polymorphism in PCSK9 Gene on the Risk and Severity of Coronary Heart Disease and Ischemic Stroke in a Tunisian Cohort.
|
24599757 |
2014 |
|
Coronary Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan.
|
19191720 |
2009 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan.
|
19191720 |
2009 |
|
Coronary heart disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study, we have determined the relative frequency of the R46L, I474V and E670G variants in the PCSK9 (protein convertase subtilisin/kexin type 9) gene and its association with plasma lipid levels and CHD (coronary heart disease) in healthy U.K. men and patients with clinically defined definite FH (familial hypercholesterolaemia).
|
17550346 |
2007 |
|
Coronary Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Haplotype 3 encompassing the E670G variant is an independent determinant of plasma LDL-C levels and the severity of coronary atherosclerosis.
|
15893176 |
2005 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, the current meta-analysis highlighted that variant allele of OLR1 rs11053646 G > C and PCSK9 rs505151 A > G may contribute to the susceptibility risk of ischemic stroke.
|
26666837 |
2015 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
As expected, the incidence of E670G was significantly important in IS subgroup than control group (0.122 vs. 0.073, p = 0.032).
|
24599757 |
2014 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In CAD patients, the AG genotype of PSCK9 rs505151 is associated with diabetes and a positive family history of CAD.
|
30947598 |
2020 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In CAD patients, the AG genotype of PSCK9 rs505151 is associated with diabetes and a positive family history of CAD.
|
30947598 |
2020 |
|
Malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
For each polymorphism, the genotype distribution among the three health conditions was statistically insignificant, but for the hypercholesterolemic E670G polymorphism, a trend towards association of the minor allele with malaria severity was observed (P = 0.035).
|
29447211 |
2018 |