|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The presence of the rs5065 ANP polymorphism is potentially associated with a reduced risk of CAD as well as with reduced severity of CAD independent of the general risk factors of CAD.
|
24487939 |
2014 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent.
|
22170009 |
2012 |
|
Coronary Artery Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The MA of rs5065 ANP gene variant associates with increased susceptibility to ACS and has unfavorable prognostic value in CAD.
|
22575314 |
2012 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Minor alleles of NPPA rs5068, rs5065 and rs198358 were associated with less history of hypertension; minor alleles of NPPA rs5068 and rs198358 was also associated with higher circulating natriuretic peptide levels (p=0.003 to p=0.04).
|
21276798 |
2011 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNPs) in NPPA, rs5063 and rs5065, result in amino acid changes of the primary peptide and have been previously implicated in conditions associated with AF, including stroke and hypertension.
|
20543198 |
2010 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Hazard ratios (95% CIs) for incident hypertension were 0.88 (0.80 to 0.96; P=0.005) for the rs5063 variant and 0.95 (0.90 to 1.00; P=0.068) for the rs5065 variant.
|
17984371 |
2007 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association between the atrial natriuretic peptide rs5065 gene polymorphism and the presence and severity of coronary artery disease in an Iranian population.
|
24487939 |
2014 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association between the atrial natriuretic peptide rs5065 gene polymorphism and the presence and severity of coronary artery disease in an Iranian population.
|
24487939 |
2014 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease.
|
22575314 |
2012 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease.
|
22575314 |
2012 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Atrial natriuretic peptide genetic variant rs5065 and risk for cardiovascular disease in the general community: a 9-year follow-up study.
|
24041948 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent.
|
22170009 |
2012 |
|
Cardioembolic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, in logistic analysis for Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification of ischemic stroke, nonsynonymous rs5065 (STOP152Arg) and rs5067 in 3'UTR of NPPA, which were in complete linkage disequilibrium, showed significant associations with cardioembolic stroke.
|
22400494 |
2012 |
|
Stable angina
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cox proportional hazard analysis tested by 4 models confirmed higher major adverse cardiovascular events risk in rs5065 MA carriers in both SA and rSA cohorts.
|
22575314 |
2012 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three hundred ninety-three control subjects and 1,004 patients undergoing coronary angiography for suspected CAD (432 stable angina [SA], 572 acute coronary syndrome [ACS]) were genotyped for rs5065 ANP gene variant.
|
22575314 |
2012 |
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNPs) in NPPA, rs5063 and r</span>s5065, result in amino acid changes of the primary peptide and have been previously implicated in conditions associated with AF, including stroke and hypertension.
|
20543198 |
2010 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNPs) in NPPA, rs5063 and rs5065, result in amino acid changes of the primary peptide and have been previously implicated in conditions associated with AF, including stroke and hypertension.
|
20543198 |
2010 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The C allele of rs5065 was associated with asthma in the screening cohort but not in the replicate.
|
18294255 |
2008 |