|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
The low expression and hyper-methylation of miR-124 was strongly associated with poor prognosis, and genetic variations of miR-124 rs531564 affected prognosis in cancer patients.
|
30062087 |
2018 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
The low expression and hyper-methylation of miR-124 was strongly associated with poor prognosis, and genetic variations of miR-124 rs531564 affected prognosis in cancer patients.
|
30062087 |
2018 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, the findings of this meta-analysis support an association between miR-124-1 rs531564 polymorphism and cancer risk.
|
30108465 |
2018 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, the findings of this meta-analysis support an association between miR-124-1 rs531564 polymorphism and cancer risk.
|
30108465 |
2018 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
MicroRNA-124 rs531564 Polymorphism and Cancer Risk: A Meta-analysis.
|
26625819 |
2015 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
A common polymorphism (rs531564, C>G) in the pri-miR-124 has been recently studied in connection with cancer risk.
|
26423518 |
2015 |
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
MicroRNA-124 rs531564 Polymorphism and Cancer Risk: A Meta-analysis.
|
26625819 |
2015 |
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
A common polymorphism (rs531564, C>G) in the pri-miR-124 has been recently studied in connection with cancer risk.
|
26423518 |
2015 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Stratified analysis by cancer type revealed that rs531564 variant was associated with gastric cancer, cervical cancer, esophageal squamous cell carcinoma and colorectal cancer risk.
|
30108465 |
2018 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results showed that rs4919510 was significantly associated with a decreased susceptibility to CRC in co-dominant, allele and recessive genetic models, and the protective role of rs4919510 allele G and genotype GG was more pronounced among stage 0-II cases; significant association between rs531564 and poor RFS was observed in cases undergoing adjuvant chemo-radiotherapy in co-dominant, allele and dominant models; moreover, there was a positive association between rs7372209 and recurrence-free survival in stage II cases in co-dominant and over-dominant models; additionally, a cumulative effect of rs531564 and rs7372209 at-risk genotypes with hazard ratio at 1.30 and 1.95 for one and two at-risk genotypes was examined in stage II cases, respectively.
|
27713147 |
2016 |
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest that pri-miR-124 rs531564 polymorphism may be a genetic modifier for developing CRC.
|
26423518 |
2015 |
|
Squamous cell carcinoma of esophagus
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our findings are the first to be reported that the miR-124 rs531564 polymorphism decreased ESCC risk in the Chinese Kazakh population.
|
29227754 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
|
0.020 |
GeneticVariation
|
BEFREE |
The miR-124 rs531564 polymorphism showed no significant association with histological stage, lymph node metastasis, depth of invasion, or tumor/node/metastasis stage.
|
29227754 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
Stratified analysis by cancer type revealed that rs531564 variant was associated with gastric cancer, cervical cancer, esophageal squamous cell carcinoma and colorectal cancer risk.
|
30108465 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
Pri-miR-124 rs531564 polymorphism and colorectal cancer risk.
|
26423518 |
2015 |
|
Secondary malignant neoplasm of lymph node
|
|
0.020 |
GeneticVariation
|
BEFREE |
Additionally, pri-miR-124 rs531564 polymorphism was significantly associated with the decreased risk of poor differentiation and lymph node metastasis of CRC.
|
26423518 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data showed that the C allele of rs531564 in miR-124a may protect against T2DM (P=0.009, OR=0.758; 95%CI: 0.616-0.933).
|
26640407 |
2015 |
|
Squamous cell carcinoma of esophagus
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.
|
24945256 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two polymorphisms were associated with T2DM susceptibility: in particular, the G allele of rs895819 in hsa-mir-27a has shown a significantly protective effect (OR = 0.58 and P = 0.008), while the G allele of rs531564 in hsa-mir-124a appears to be a risk allele (OR = 2.15, P = 0.008).
|
23532299 |
2013 |
|
Anal abscess
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, miR-124 polymorphism rs531564 is involved with the pathogenesis of anal abscess in AF patients, and the presence of rs531564 may increase the incidence of anal abscess via upregulating the expression of IL-6R, TNF-α, IFN-γ, and IL-4.
|
31148212 |
2019 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The meta-analysis indicated that the G allele or GG genotype of miR-146a rs2910164 was associated with a significantly increased risk for DM compared with C allele or GC/CC genotype in Latin American population; CC genotype of miR-27a rs895819 polymorphism was associated with a significantly decreased risk for DM in Asian population compared with the TT genotype; patients carrying with CC genotype of miR-124 rs531564 had a lower probability to develop DM regardless of ethnicity; no associations were identified between polymorphisms in miR-375, miR-128a, miR-194a and the susceptibility to DM.
|
31689753 |
2019 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to clarify whether genetic variations in four miRNA genes (miR-143 rs4705342, miR-122 rs17669, miR-126 rs4636297, and miR-124 rs531564) contribute to IS susceptibility.
|
30895838 |
2019 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
MiR-124 rs531564-G may be associated with a lower risk of female neoplasms.
|
31615040 |
2019 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings did not support an association between miR-100 rs1834306, miR-124-1 rs531564, miR-605 rs2043556 and miR-4293 rs12220909 polymorphism and the risk of BC.
|
29317318 |
2018 |
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
There is a strong link between pri-miR-124-1 rs531564 and STAT3 rs1053023 and gastric cancer that may be pathogenic, and so worthy of further investigation.
|
29938592 |
2018 |