|
Arteriosclerosis
|
|
0.070 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) Ser128Arg in the E-selectin gene is overrepresented in certain patient groups with atherosclerosis or restenosis.
|
15546947 |
2005 |
|
Atherosclerosis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Ser 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis.
|
22648254 |
2012 |
|
Arteriosclerosis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
Arteriosclerosis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Ser 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis.
|
22648254 |
2012 |
|
Arteriosclerosis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40--88 years and 314 asymptomatic men aged 30--80 years from the Epidemiology of Coronary Artery Calcification Study.
|
11466561 |
2001 |
|
Atherosclerosis
|
|
0.070 |
GeneticVariation
|
BEFREE |
Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40--88 years and 314 asymptomatic men aged 30--80 years from the Epidemiology of Coronary Artery Calcification Study.
|
11466561 |
2001 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
E-selectin S128R polymorphism and severe coronary artery disease in Arabs.
|
16756647 |
2006 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China.
|
16061120 |
2005 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
The interaction of classical risk factors for CAD with S128R polymorphism in our study population showed that the significant determinants of coronary artery disease were presence of diabetes, hypertension, smoking habit, elevated serum triglycerides and low HDL.
|
19942746 |
2009 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
In subjects suffering from diabetes mellitus type 2 the E-selectin S128R polymorphism is not associated with coronary artery disease nor with an increased risk for myocardial infarction.
|
15013273 |
2003 |
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease.
|
17578587 |
2007 |
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation
|
BEFREE |
All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study).
|
9668170 |
1998 |
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation
|
BEFREE |
In subjects suffering from diabetes mellitus type 2 the E-selectin S128R polymorphism is not associated with coronary artery disease nor with an increased risk for myocardial infarction.
|
15013273 |
2003 |
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results suggested there is an increase in the risk of CAD conferred by the Ser128Arg polymorphism and the thr715Pro polymorphism may be a protective factor of MI.
|
24498435 |
2014 |
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results suggest that the E-selectin Ser128Arg polymorphism can functionally alter leukocyte-endothelial interactions as well as biochemical and biological consequences, which may account for the pathogenesis of myocardial infarction.
|
12649084 |
2003 |
|
Cerebrovascular accident
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results indicate that the individuals bearing AC genotype of E-selectin gene polymorphism (S128R) are more prone to stroke than AA genotype.
|
24249306 |
2014 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
Association of E-selectin gene polymorphism (S128R) with ischemic stroke and stroke subtypes.
|
24249306 |
2014 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, a polymorphism in the E-selectin gene (S128R) has been associated with higher E-selectin levels in patients with diabetes mellitus and with premature coronary artery disease.
|
15013273 |
2003 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
E-selectin gene (S128R) polymorphism in hemorrhagic stroke: comparison with ischemic stroke.
|
25168603 |
2014 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among women with low levels of subclinical inflammation (C-reactive protein levels below the population median), S128R R allele carriers had a diabetes risk factor-adjusted relative risk of incident diabetes of 1.71 (95% confidence interval, 1.04 to 2.81) relative to those with the SS genotype.
|
15833936 |
2005 |
|
Cerebrovascular accident
|
|
0.030 |
GeneticVariation
|
BEFREE |
The genotypic and allelic variation between the ischemic and hemorrhagic stroke, suggests that E-selectin S128R mediated amplification of leukocytes onto endothelial cells, leading to secondary damage of brain cells is more pronounced in hemorrhagic stroke.
|
25168603 |
2014 |
|
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
The interaction of classical risk factors for CAD with S128R polymorphism in our study population showed that the significant determinants of coronary artery disease were presence of diabetes, hypertension, smoking habit, elevated serum triglycerides and low HDL.
|
19942746 |
2009 |
|
Cerebrovascular accident
|
|
0.030 |
GeneticVariation
|
BEFREE |
The frequency of minor allele (R) and heterozygous (RS) genotype of E-selectin S128R polymorphism was significantly higher in the stroke patients than in the controls.
|
19420919 |
2009 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our study demonstrates that the E-selectin S128R and L554F polymorphisms are associated with susceptibility to ischemic stroke.
|
19420919 |
2009 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
E-selectin S128R "C" allele may confer an increased susceptibility to pancreatic cancer development, while its carriage status does not appear to be related to the aggressive features of this malignancy.
|
20607758 |
2010 |