|
Lupus Erythematosus, Systemic
|
|
0.030 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests important roles for the mir-499 rs3746444 polymorphism in RA, especially in the Caucasian population and for miR-146a rs57095329 polymorphism in SLE.
|
25218914 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of our meta-analysis suggest that miR-146a rs57095329 and rs2431697 SNPs are associated with SLE susceptibility.
|
24803388 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.030 |
GeneticVariation
|
BEFREE |
To explore why the expression of miR-146a is reduced in SLE patients, we conducted short parallel sequencing of potentially regulatory regions of miR-146a and identified a novel genetic variant (rs57095329) in the promoter region exhibiting evidence for association with SLE that was replicated independently in 7,182 Asians (P(meta) = 2.74×10(-8), odds ratio = 1.29 [1.18-1.40]).
|
21738483 |
2011 |
|
Seizures
|
|
0.020 |
GeneticVariation
|
BEFREE |
miR-146a rs57095329 polymorphism might be involved in the genetic susceptibility to drug-resistance and seizure severity in childhood epilepsy patients.
|
27310665 |
2016 |
|
Epilepsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, the miR-146a rs57095329 A/G genotypes were significantly associated with increased drug-resistance risk of epilepsy patients in allelic comparison (OR=2.363, 95%CI=1.608-3.472, P<0.001), heterozygote model (OR=2.341, 95%CI=1.301-4.211, P=0.005), homozygote model (OR=1.791, 95%CI=1.239-2.589, P=0.002), dominant model (OR=2.625, 95%CI=1.558-4.425, P<0.001), and recessive model (OR=2.336, 95%CI=1.166-4.673, P=0.017).
|
27310665 |
2016 |
|
Seizures
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data indicate that the rs57095329 polymorphism in the promoter region of miR-146a is involved in the genetic susceptibility to DRE and the seizures frequency.
|
25891929 |
2015 |
|
Epilepsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this report, we performed a case-control study to analyze the relationship between the two potentially functional single nucleotide polymorphisms (SNPs) of the miR-146a gene (rs2910464 and rs57095329) and the risk of epilepsy in a Chinese population comprising 249 cases and 249 healthy controls.
|
25891929 |
2015 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Statistical analysis revealed the heterozygous AG genotype of the rs57095329 was significantly decreased in the cases when compared to the controls (OR-0.45, CI -0.24 to 0.85, p value-0.02) indicating an inverse association of this genotype with prostate cancer.
|
29594807 |
2020 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Statistical analysis revealed the heterozygous AG genotype of the rs57095329 was significantly decreased in the cases when compared to the controls (OR-0.45, CI -0.24 to 0.85, p value-0.02) indicating an inverse association of this genotype with prostate cancer.
|
29594807 |
2020 |
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
|
30576465 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
|
30576465 |
2019 |
|
Mucocutaneous Lymph Node Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In KD-CAL group, the allele frequency of A was higher than that in KD-WO group at locus rs57095329 A/G polymorphisms of miR-146a gene (χ<sup>2</sup> = 4.745, P = 0.035), carriers with allele A were at 2.422 times higher risk of getting coronary artery lesions than those of non-carriers (χ<sup>2</sup> = 4.745, P = 0.035, OR = 2.422, 95%CI = 1.073-5.465), while there was no significant difference of genotype frequency of AA, AG, and GG types between KD-CAL group and KD-WO group (P > 0.05).
|
30291383 |
2019 |
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
|
30576465 |
2019 |
|
Juvenile rheumatoid arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings did not support the genetic association between miR-146a rs2910164 (G/C) and JRA susceptibility, as well as the association of miR-196a-2 rs11614913 (C/T), miR-146a rs2431697, miR-146a rs57095329, miR-149 rs22928323 with arthritis.
|
31235484 |
2019 |
|
Mutism
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, the SNP of rs57095329 showed statistical significances with the appearances of mutism and the positive of cerebrospinal fluid (CSF) protein 14-3-3 in sCJD patients, while the SNP of ZBTB38-RASA2 was significantly related with the appearance of myoclonus in sCJD patients.
|
29216791 |
2018 |
|
Creutzfeldt-Jakob Disease, Sporadic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, the SNP of rs57095329 showed statistical significances with the appearances of mutism and the positive of cerebrospinal fluid (CSF) protein 14-3-3 in sCJD patients, while the SNP of ZBTB38-RASA2 was significantly related with the appearance of myoclonus in sCJD patients.
|
29216791 |
2018 |
|
Myoclonus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, the SNP of rs57095329 showed statistical significances with the appearances of mutism and the positive of cerebrospinal fluid (CSF) protein 14-3-3 in sCJD patients, while the SNP of ZBTB38-RASA2 was significantly related with the appearance of myoclonus in sCJD patients.
|
29216791 |
2018 |
|
Fatal Familial Insomnia
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, a significant association of the SNP of rs57095329 in miR-146a showed the association with the susceptibility of FFI.
|
29216791 |
2018 |
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of this study was to identify the association between the MiR-146a single nucleotide polymorphisms (SNPs) (rs2910164, rs57095329, and rs73318382), the MiR-196a2 (rs11614913) SNP and chronic periodontitis.
|
28384038 |
2017 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The miR-146a SNPs rs2910164, rs57095329, rs2431697 are associated with susceptibility to certain autoimmune diseases.
|
27098222 |
2016 |
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests important roles for the mir-499 rs3746444 polymorphism in RA, especially in the Caucasian population and for miR-146a rs57095329 polymorphism in SLE.
|
25218914 |
2016 |
|
Drug Resistant Epilepsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data indicate that the rs57095329 polymorphism in the promoter region of miR-146a is involved in the genetic susceptibility to DRE and the seizures frequency.
|
25891929 |
2015 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present study was to analyze the potential association between two functional miR-146a polymorphisms (rs2910164 and rs57095329) and multiple sclerosis (MS) in the Han Chinese population.
|
25591770 |
2015 |
|
Severe Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, we confirmed that the two SNPs rs2910164 and rs57095329 could functionally affect the miR-146a expression levels and the reduction of miR146a was accompanied with the upregulation of the expression levels of TRAF-6 and IRAK-1 in severe sepsis patients.
|
24701036 |
2014 |
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study has analyzed the association of sepsis with two functional miR-146a gene SNPs rs2910164 G/C and rs57095329 A/G in a Chinese Han population (226 sepsis cases; 206 healthy controls).
|
24701036 |
2014 |