|
Allergic Reaction
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
For those with childhood farm exposure, carriers of the TLR6-rs1039559 T-allele (p-interaction = 0.009) and TLR6-rs5743810 C-allele (p-interaction = 0.02) were associated with lower risk of early-onset asthma.
|
28262750 |
2017 |
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genotyping of the Ser249Pro polymorphism in 68 unrelated adult patients and 132 unrelated children with asthma, 185 unrelated patients with COPD, 295 unrelated individuals with AD and 212 healthy control subjects was performed by restriction enzyme digestion.
|
16188043 |
2005 |
|
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Utilizing this SNP (Ser249Pro), we performed exploratory nested case-control disease-association studies, including one involving 56 African Americans with asthma and 93 African American controls.
|
15266299 |
2004 |
|
Tuberculosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).
|
24984237 |
2014 |
|
Dermatitis, Atopic
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, 11/60 (18%) children with TLR6 rs5743810 C/T versus 36/73 (49%) children of other genotypes had atopic eczema at follow up.
|
24445834 |
2014 |
|
Tuberculosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR6 C745T is associated with decreased TB risk.
|
23691034 |
2013 |
|
Dermatitis, Atopic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of the Ser249Pro polymorphism in 68 unrelated adult patients and 132 unrelated children with asthma, 185 unrelated patients with COPD, 295 unrelated individuals with AD and 212 healthy control subjects was performed by restriction enzyme digestion.
|
16188043 |
2005 |
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the TLR1 rs5743611, TLR4 rs4986790, TLR4 rs4986791, TLR6 rs5743810, and TLR9 rs352140 polymorphisms were significantly associated with the risk of IBD in Caucasians.
|
30617966 |
2019 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Global analysis revealed no significant association between the TLR6 rs3796508 and rs5743810 and CRC in this population.
|
31281474 |
2019 |
|
Lower respiratory tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings reveal that single-nucleotide polymorphisms within toll-interleukin 1 receptor domain-containing adaptor protein (<i>TIRAP</i>) alone or in combination with TLR1 N248S, TLR1 I602S, or TLR6 S249P polymorphisms contributes to various degree of susceptibility to recurrent pneumococcal LRTI in children by modulating the inflammatory response.
|
30131804 |
2018 |
|
Malaria, Vivax
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data presented in this study suggests the influence of polymorphisms TLR4 (A299G), TLR6 (S249P) and TLR9 (-1486C/T) on the production of circulating cytokines during Pv-malaria.
|
29656958 |
2018 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Importantly, the rs5743810 Pro allele could be a potential BC</span> diagnostic biomarker in this ethnic population.
|
30388713 |
2018 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Importantly, the rs5743810 Pro allele could be a potential BC</span> diagnostic biomarker in this ethnic population.
|
30388713 |
2018 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant correlations with atherosclerosis susceptibility were found for the TLR1 rs5743551 polymorphism (dominant model: 95% CI 1.03-1.79; recessive model: 95% CI 0.28-0.97; allele model: 95% CI 1.07-1.69), TLR1 rs5743611 polymorphism (dominant model: 95% CI 0.56-0.98) and TLR6 rs5743810 polymorphism (recessive model: 95% CI 0.56-0.92) in overall analyses.
|
28474755 |
2017 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant correlations with atherosclerosis susceptibility were found for the TLR1 rs5743551 polymorphism (dominant model: 95% CI 1.03-1.79; recessive model: 95% CI 0.28-0.97; allele model: 95% CI 1.07-1.69), TLR1 rs5743611 polymorphism (dominant model: 95% CI 0.56-0.98) and TLR6 rs5743810 polymorphism (recessive model: 95% CI 0.56-0.92) in overall analyses.
|
28474755 |
2017 |
|
Complicated malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed the PP genotype of TLR6 (P249S) to be significantly more common in UM (P < 0.0001), whereas the 'SS' genotype was the risk factor for SM including its sub-clinical categories.
|
26621243 |
2016 |
|
Endometritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among African Americans, the TLR6 rs5743810 T allele significantly decreased endometritis and/or UGTI (OR, 0.4 [95% CI, .2-.9]; P = .04).
|
23255565 |
2013 |
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
|
Malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR-6 S249P SNP showed an excess of homozygotes for the TLR-6 249P allele in asymptomatic persons, compared with patients with mild malaria due to any Plasmodium species (OR 2.1; 95% confidence interval [CI], 1.1- 4.2; P= .01; P(corrected)= .05), suggesting that the TLR-6 249S allele may be a risk factor for malaria (OR, 2.0; 95% CI, 1.1-3.7; P=0.01; P(corrected)= .05).
|
18662133 |
2008 |
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a negative association between TLR6 S249P and ulcerative colitis with proctitis only (P = .026, OR [95% CI] 0.223 [0.096-0.705]).
|
16374251 |
2006 |
|
Proctitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a negative association between TLR6 S249P and ulcerative colitis with proctitis only (P = .026, OR [95% CI] 0.223 [0.096-0.705]).
|
16374251 |
2006 |
|
Eczema
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping of the Ser249Pro polymorphism in 68 unrelated adult patients and 132 unrelated children with asthma, 185 unrelated patients with COPD, 295 unrelated individuals with AD and 212 healthy control subjects was performed by restriction enzyme digestion.
|
16188043 |
2005 |
|
Invasive aspergillosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis of recipient SNP data showed that the presence of TLR1 239G > C (Arg80 > Thr) or the presence of both TLR1 743A > G (Asn248 > Ser) and TLR6 745C > T (Ser249 > Pro) is associated with IA (odds ratio = 1.30, 95% confidence interval = 1.13 to 1.50; P < .001).
|
16461792 |
2005 |
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease.
|
16188043 |
2005 |