|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
We did not observe any association between TLR9 polymorphisms (rs187084, rs352140, rs5743836 and rs352139) and SLE under any model, after excluding the data that were inconsistent with Hardy-Weinberg equilibrium (HWE).
|
28528372 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, no significant association between TLR9 SNPs (rs352139, rs352140, and rs5743836) and SLE risk was identified.
|
26643792 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
We suggest that TLR7 rs179008 and TLR9 rs5743836 can be considered SLE susceptibility factors for women of European descent in our population.
|
22065095 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
No association was found between SLE and the 2 alleles of the rs5743836 (TLR9) polymorphism in all overall subjects or in Europeans, but one study showed a significant association in Asians (OR 4.243; 95% CI 1.487, 12.10; p=0.007).
|
22325161 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
We performed a case-control association study and genotyped 409 Caucasian women with SLE and 509 Caucasian healthy female controls using TaqMan allelic discrimination (rs5744168) or polymerase chain reaction-restriction fragment length polymorphism analysis (rs5743836).
|
17516623 |
2007 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that the rs187084 polymorphism may be associated with an elevated cancer risk, whereas polymorphisms of rs352140 and rs5743836 may play protective roles in the development of breast and digestive system cancers, respectively.
|
25339018 |
2014 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that the rs187084 polymorphism may be associated with an elevated cancer risk, whereas polymorphisms of rs352140 and rs5743836 may play protective roles in the development of breast and digestive system cancers, respectively.
|
25339018 |
2014 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no significantly increased cancer risk was detected to be associated with rs187084 and rs5743836 either the overall or subgroup estimation.
|
23990988 |
2013 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no significantly increased cancer risk was detected to be associated with rs187084 and rs5743836 either the overall or subgroup estimation.
|
23990988 |
2013 |
|
Crohn Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Among the CD risk loci, rs7927894 (P = 0.007), rs7746082 (P=0.011), rs2872507 (P = 0.014), together with rs5743836 (P = 0.010) were univariately associated with colonic transit at 24 or 48 h. Specific tests for genetic interactions between loci revealed potential association of genes that influence neural, barrier, or mast cell function with colonic transit.
|
21752155 |
2011 |
|
Crohn Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphisms (SNPs) -1237T/C (rs5743836) and 2848A/G (rs352140=p.Pro545Pro) in TLR9, the main CD-associated variants within the genes for NOD2, IL23R, ATG16L1, and variants in the IBD5 locus and in the DLG5 gene were assessed in 956 patients with IBD (606 CD and 350 ulcerative colitis) and in 792 healthy controls.
|
19455129 |
2009 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings show that TLR9 rs5743836 and rs187084 polymorphisms are associated with a higher risk of carcinogenesis gastric, and that TLR9 mRNA levels can be modulated by TLR9-1237 TC + CC variant genotypes and <i>H. pylori</i> infection.
|
31798780 |
2019 |
|
Chronic gastritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A case-control study was conducted to evaluate two TLR9 SNPs (TLR9<i>-</i>1237 TC-rs5743836 and TLR9<i>-</i>1486 CT-rs187084) in chronic gastritis (CG) and GC patients.
|
31798780 |
2019 |
|
Spondylarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphism <i>rs5743708</i> for the <i>TLR2</i> and the <i>rs187084_rs5743836 TLR9</i> haplotypes appear to be involved in the development of clinical forms of SpA and can be a possible therapeutic target for the spondyloarthritis.
|
31781672 |
2019 |
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping was performed to detect -196 to -174 del polymorphism and G2258A SNP (Arg753Gln, rs5743708) in TLR2 gene and -T1237C (rs5743836) and G2848A (rs352140) SNP in TLR9 gene in patients with pulmonary TB and healthy controls.
|
29675696 |
2018 |
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of the screened polymorphisms, TT genotype of the missense variant TLR5 (rs5744174) (NM_003268.5:c.1846T>C (p.Phe616Leu) is significantly more frequent in the control group than CHB patients (P<0.001), presence of TT genotype of the upstream variant TLR9 (rs5743836) (NM_017442.3:c.-1237T>C) is more frequent in CHB group (P=0.043).
|
29276096 |
2018 |
|
Thrombophilia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed TLR9 rs5743836 polymorphism in Malmö thrombophilia study patients; a prospective follow-up study of 1465 VTE patients by Taqman PCR.
|
28321710 |
2017 |
|
Meningococcal meningitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim was to analyse TLR2 rs5743708, TLR2 rs4696480, TLR4 rs4986790, TLR9 rs5743836, and TLR9 rs352140 single nucleotide polymorphisms (SNPs) in children with pneumococcal and meningococcal meningitis and their family members.
|
28487240 |
2017 |
|
Venous Thromboembolism
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that TLR9 rs5743836 polymorphism is an independent risk factor for VTE recurrence in female patients but not in males.
|
28321710 |
2017 |
|
HIV Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
In European descendants, the TLR9 rs57</span>43836 C carriers displayed a higher susceptibility to HIV in</span>fection [dominant, Odds Ratio (OR)=1.53; 95% CI: 1.05-2.23; P=0.027].
|
28062211 |
2017 |
|
Community acquired pneumonia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We studied common polymorphisms in the genes of proinflammatory cytokines (IL6 rs1800795, IL8 rs4073, IL1B rs16944), anti-inflammatory cytokines (IL10 rs1800896, IL4 rs2243250, IL13 rs20541) and toll-like receptors (TLR2 rs5743708 and rs4696480, TLR4 rs4986791, TLR9 rs352139, rs5743836 and rs187084) in patients with community-acquired pneumonia (CAP) (390 cases, 203 controls) and nosocomial pneumonia (355 cases, 216 controls).
|
27725770 |
2016 |
|
Meningitis, Bacterial
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant differences were observed in the association between the TLR9-1237 rs5743836 polymorphism and the risk of bacterial meningitis in the codominant, dominant, or recessive models.
|
27525854 |
2016 |
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TRAF3 (rs12147254) AA homozygosity (RR = 2.770, P = 0.0392), TLR9 (rs5743836) C wild-type allele (RR = 2.542, P = 0.0096) as well as TLR9 (rs187084) T allele (RR = 13.396, P < 0.0001) and its homozygosity (RR = 11.805, P < 0.0001) were more frequent among patients with AML than healthy individuals.
|
26919710 |
2016 |
|
Latent Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TC genotype frequency of SNP rs5743836 in TLR9 was significantly higher in the LTBI group than in the HC group (OR = 1.664; 95% CI: 1.201-2.306).
|
25928077 |
2015 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs352140 polymorphism had a protective effect on breast cancer (GA vs GG: OR=0.77, 95% CI=0.66-0.89), whereas the rs5743836 polymorphism was likely protective for digestive system cancers (CC+TC vs TT: OR=0.81, 95% CI=0.66-0.98).
|
25339018 |
2014 |