rs578776, CHRNA3

N. diseases: 13
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
NEUROTICISM
CUI: C1842981
Disease: NEUROTICISM
0.010 GeneticVariation BEFREE The minor alleles of four CHRNA5 polymorphisms (rs588765, rs601079, rs680244 and rs555018) and three CHRNA3 polymorphisms (rs578776, rs6495307 and rs3743078) showed associations with neuroticism. 24588897 2014
Attention deficit hyperactivity disorder
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
0.010 GeneticVariation BEFREE Our results demonstrate that the minor alleles of two polymorphisms (rs578776 and rs3743078) in the CHRNA3 gene are associated with an increased risk of tobacco smoking only among patients with ADHD. 24375168 2014
Malignant neoplasm of mouth
CUI: C0153381
Disease: Malignant neoplasm of mouth
0.010 GeneticVariation BEFREE While no association was observed between rs16969968 and oral cancer risk (OR =  1.01, 95% CI =  0.83- 1.22), rs578776 was modestly associated with a 16% decreased risk of oral cancer (OR =  0.84, 95% CI =  0.72- 0.98). 24505444 2014
Alcoholic Intoxication, Chronic
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
0.010 GeneticVariation BEFREE We also observed two SNPs associated with alcohol dependence, that is, rs615470 in CHRNA5 (OR=0.77, P=0.0006) and rs578776 (OR=0.78, P=0.001). 20485328 2010