|
Malignant neoplasm of lung
|
|
0.740 |
GeneticVariation
|
BEFREE |
Gene polymorphisms of CHRNA3 (rs578776) and CHRNA4 (rs1044396 and rs2229959) were associated with the success of smoking cessation after the diagnosis of lung cancer, which should be considered in the management of smoking cessation after patients are diagnosed with lung cancer.
|
31402126 |
2020 |
|
Malignant neoplasm of lung
|
|
0.740 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggested both rs578776 and rs938682 were significantly associated with the susceptibility of lung cancer.
|
26831765 |
2016 |
|
Malignant neoplasm of lung
|
|
0.740 |
GeneticVariation
|
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
|
Malignant neoplasm of lung
|
|
0.740 |
GeneticVariation
|
BEFREE |
Two variants in the nicotinic acetylcholine receptor subunit genes CHRNA5 and CHRNA3 on 15q25, rs16969968 and rs578776, were associated with cotinine (P = 0.001 and 0.03, respectively) in current smokers and with lung cancer risk (P < 0.001 and P = 0.001, respectively).
|
21862624 |
2011 |
|
Malignant neoplasm of lung
|
|
0.740 |
GeneticVariation
|
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
Malignant neoplasm of lung
|
|
0.740 |
GeneticVariation
|
GWASDB |
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
|
19654303 |
2009 |
|
Smoking Behaviors
|
|
0.700 |
GeneticVariation
|
GWASDB |
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
20418888 |
2010 |
|
Smoking Behaviors
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
|
20418889 |
2010 |
|
Adenocarcinoma of lung (disorder)
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
|
19836008 |
2009 |
|
Nicotine Dependence
|
|
0.050 |
GeneticVariation
|
BEFREE |
We investigated six variants known to influence nicotine addiction or alcohol metabolism, including rs16969968 (CHRNA5), rs578776 (CHRNA3), rs1229984 (ADH1B), rs698 (ADH1C), rs1573496 (ADH7), and rs4767364 (ALDH2).
|
24505444 |
2014 |
|
Nicotine Dependence
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our findings suggest that the rs578776 risk variant influences susceptibility to ND by dampening the response of the ACC to reward feedback, without recruiting the striatum or orbitofrontal cortex during feedback or anticipation.
|
23689675 |
2013 |
|
Nicotine Dependence
|
|
0.050 |
GeneticVariation
|
BEFREE |
The purpose of this study was to analyse the association of smoking status and smoking-related phenotypes (included nicotine dependence) with 17 candidate genetic variants: CYP2A6*1×2, CYP2A6*2 (1799T>A) [rs1801272], CYP2A6*9 (-48T>G) [rs28399433], CYP2A6*12, CYP2A13*2 (3375C>T) [rs8192789], CYP2A13*3 (7520C>G), CYP2A13*4 (579G>A), CYP2A13*7 (578C>T) [rs72552266], CYP2B6*4 (785A>G), CYP2B6*9 (516G>T), CHRNA3 546C>T [rs578776], CHRNA5 1192G>A [rs16969968], CNR1 3764C>G [rs6928499], DRD2-ANKK1 2137G>A (Taq1A) [rs1800497], 5HTT LPR, HTR2A -1438A>G [rs6311] and OPRM1 118A>G [rs1799971].
|
22046326 |
2011 |
|
Nicotine Dependence
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here we test the hypothesis that the nicotinic receptor genes CHRNA5 (rs16969968), CHRNA3 (rs578776), CHRNB3 (rs13277254) and CHRND (rs12466358) modify the risk for nicotine dependence associated with peer smoking.
|
20840187 |
2010 |
|
Nicotine Dependence
|
|
0.050 |
GeneticVariation
|
BEFREE |
The CHRNA3 SNP rs578776, which has a low correlation with rs16969968, is associated with nicotine dependence in European-Americans but not in African-Americans.
|
19706762 |
2009 |
|
Primary malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
Gene polymorphisms of CHRNA3 (rs578776) and CHRNA4 (rs1044396 and rs2229959) were associated with the success of smoking cessation after the diagnosis of lung cancer, which should be considered in the management of smoking cessation after patients are diagnosed with lung cancer.
|
31402126 |
2020 |
|
Carcinoma of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
Gene polymorphisms of CHRNA3 (rs578776) and CHRNA4 (rs1044396 and rs2229959) were associated with the success of smoking cessation after the diagnosis of lung cancer, which should be considered in the management of smoking cessation after patients are diagnosed with lung cancer.
|
31402126 |
2020 |
|
Carcinoma of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggested both rs578776 and rs938682 were significantly associated with the susceptibility of lung cancer.
|
26831765 |
2016 |
|
Primary malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggested both rs578776 and rs938682 were significantly associated with the susceptibility of lung cancer.
|
26831765 |
2016 |
|
Primary malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
Two variants in the nicotinic acetylcholine receptor subunit genes CHRNA5 and CHRNA3 on 15q25, rs16969968 and rs578776, were associated with cotinine (P = 0.001 and 0.03, respectively) in current smokers and with lung cancer risk (P < 0.001 and P = 0.001, respectively).
|
21862624 |
2011 |
|
Carcinoma of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
Two variants in the nicotinic acetylcholine receptor subunit genes CHRNA5 and CHRNA3 on 15q25, rs16969968 and rs578776, were associated with cotinine (P = 0.001 and 0.03, respectively) in current smokers and with lung cancer risk (P < 0.001 and P = 0.001, respectively).
|
21862624 |
2011 |
|
Carcinoma of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
Primary malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphisms studied, rs578776 (CHRNA3) and rs16969968 (CHRNA5), did not have an association with HNC risk, but the rs16969968 homozygous genotype was associated with increased cigarette consumption intensity (OR 1.93, 95% CI 1.05-3.58).
|
31599127 |
2019 |
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphisms studied, rs578776 (CHRNA3) and rs16969968 (CHRNA5), did not have an association with HNC risk, but the rs16969968 homozygous genotype was associated with increased cigarette consumption intensity (OR 1.93, 95% CI 1.05-3.58).
|
31599127 |
2019 |
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
While no association was observed between rs16969968 and oral cancer risk (OR = 1.01, 95% CI = 0.83- 1.22), rs578776 was modestly associated with a 16% decreased risk of oral cancer (OR = 0.84, 95% CI = 0.72- 0.98).
|
24505444 |
2014 |