|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, these data suggest that the increased obesity risk linked to the N221D allele in humans may be due in part to PC1/3-induced loss of resilience to stressors rather than strictly to decreased enzymatic activity on peptide precursors.
|
31504391 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Coimmunoprecipitation of PC1/3-N222D and human PC1/3 variants associated with obesity with the endoplasmic reticulum (ER) chaperone BiP was studied in cell lines.
|
26786350 |
2016 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant associations were found with binary obesity status for rs6232 (OR = 1.15, 95% CI 1.06-1.24, P = 6.08 × 10(-6)) and rs6234/rs6235 (OR = 1.07, 95% CI 1.04-1.10, P = 3.00 × 10(-7)).
|
25784503 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In RSPlus1, heterozygotes for rs6232 had 1.5 times higher risk of obesity (OR: 1.46; 95% confidence interval: 1.04-2.03; P=0.03).
|
25031086 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis confirmed the association of PCSK1 SNPs with obesity and provides the first evidence that the association between PCSK1 rs6232 and obe</span>sity is stronger for childhood obesity than for adult obesity.
|
25355447 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These profound alterations in the cell biology of PC1/3-N222D are likely to contribute to the defective insulin biosynthetic events observed in the mutant mice and may be relevant to the dramatic contributions of polymorphisms in this gene to human obesity.
|
24828610 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The effects of this novel variant on the biosynthesis, secretion, and catalytic activity were determined; the previously-described obesity risk SNPs N221D (rs6232), Q665E/S690T (rs6234/rs6235), and the Q665E and S690T SNPs (analyzed separately) were included for comparative purposes.
|
23383060 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that common PCSK1 variants (notably rs</span>6232 and rs6235) contribute modestly to obesity in multi-ethnic American population.
|
23451278 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity.
|
22737226 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity.
|
20534142 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our data suggest that the PCSK1 rs6</span>232 and rs6235 SNPs are not major contributors to common obe</span>sity in the general population.
|
19528091 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The nonsynonymous variants rs6232, encoding N221D, and rs6234-rs6235, encoding the Q665E-S690T pair, were consistently associated with obesity in adults and children (P = 7.27 x 10(-8) and P = 2.31 x 10(-12), respectively).
|
18604207 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Increased energy intake and a more efficient metabolism contribute to the obesity in Pc1(N222D/N222D) mice.
|
16644867 |
2006 |
|
Pediatric Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition to confirming rs6232 and rs6234 in <i>PCSK1</i> as polygenic risk variants for childhood obesity, we describe an association of rs725522 with insulin metabolism.
|
28271036 |
2017 |
|
Pediatric Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis confirmed the association of PCSK1 SNPs with obesity and provides the first evidence that the association between PCSK1 rs6232 and obesity is stronger for childhood obesity than for adult obesity.
|
25355447 |
2014 |