|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, no significant difference in genotype distribution between PCOS and controls provided an insight that rs6259 polymorphism is not associated with the risk of PCOS and SHBG levels.
|
30719605 |
2019 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
Taken together, the study showed that SHBG rs6259 polymorphisms might be correlated with the risk of PCOS and the outcome of IVF-ET treatment.
|
30520140 |
2019 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests that SHBG Asp327Asn polymorphism is not associated with breast cancer risk overall, while it might be an important genetic susceptibility factor in postmenopausal Asian women for developing breast cancer.
|
22711300 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
Carrying mutant alleles of rs727428 was found to be associated with a 1.29 odds ratio (OR) for PCOS, whereas carrying mutant alleles of rs6259 associated with a 0.68 OR for PCOS.
|
23001781 |
2012 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests that SHBG Asp327Asn polymorphism is not associated with breast cancer risk overall, while it might be an important genetic susceptibility factor in postmenopausal Asian women for developing breast cancer.
|
22711300 |
2012 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Five SNPs (AHR rs2066853, ATM rs1003623, ESR1 rs2234693, GSTP1 rs1695, and SHBG rs6259) showed generally consistent results in SBCS I and SBCS II and statistically significant associations with breast cancer risk in combined analyses, mostly in subgroups defined by age or menopausal status.
|
21454829 |
2011 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
The study aims were 1) to determine whether any of four SHBG SNPs (rs1779941, rs6297, rs6259, and rs727428) are associated with PCOS and 2) to determine whether SNP genotype influences SHBG levels in PCOS women.
|
21252242 |
2011 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Five SNPs (AHR rs2066853, ATM rs1003623, ESR1 rs2234693, GSTP1 rs1695, and SHBG rs6259) showed generally consistent results in SBCS I and SBCS II and statistically significant associations with breast cancer risk in combined analyses, mostly in subgroups defined by age or menopausal status.
|
21454829 |
2011 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our observations, demonstrating the increased efficiency of D327N SHBG in counteracting estradiol action and a significantly higher frequency of Asp327Asn polymorphism in women not developing breast cancer after estrogen exposure, first provide evidence for the mechanism of D327N SHBG protective action.
|
18437557 |
2009 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our observations, demonstrating the increased efficiency of D327N SHBG in counteracting estradiol action and a significantly higher frequency of Asp327Asn polymorphism in women not developing breast cancer after estrogen exposure, first provide evidence for the mechanism of D327N SHBG protective action.
|
18437557 |
2009 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS.
|
17258903 |
2007 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Implications of gene-environment interaction in studies of gene variants in breast cancer: an example of dietary isoflavones and the D356N polymorphism in the sex hormone-binding globulin gene.
|
16982738 |
2006 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Implications of gene-environment interaction in studies of gene variants in breast cancer: an example of dietary isoflavones and the D356N polymorphism in the sex hormone-binding globulin gene.
|
16982738 |
2006 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene.
|
15894658 |
2005 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene.
|
15894658 |
2005 |
|
Polycystic Ovary Syndrome
|
|
0.060 |
GeneticVariation
|
BEFREE |
Plasma SHBG concentration was related to PCOS status, non-SHBG-bound testosterone, BMI, fasting blood glucose level, fasting insulinemia, and D327N allele v. The v allele was associated with higher SHBG levels [36.9 +/- 15.9 nmol/liter for W/v (n = 52) and 43.5 +/- 3.5 nmol/liter for v/v (n = 2)] than was the wild-type W allele [31.1 +/- 16.1 nmol/liter (n = 249); P = 0.039].
|
14764814 |
2004 |
|
Breast Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The D327N mutation of human SHBG is associated with a number of good prognostic factors in breast cancer like estrogen receptor positivity and erb2 negativity.
|
15008248 |
2003 |
|
Malignant neoplasm of breast
|
|
0.060 |
GeneticVariation
|
BEFREE |
The D327N mutation of human SHBG is associated with a number of good prognostic factors in breast cancer like estrogen receptor positivity and erb2 negativity.
|
15008248 |
2003 |
|
Male infertility
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also, genotype frequencies, allele frequency, and haplotype were all analyzed in both groups.There were statistical differences in A allele frequency (P = .017) and GA genotype frequency (P = .016) of SHBG gene rs6259 locus and in CC genotype frequency of SHBG gene rs727428 locus (P = .034) between the 2 groups.Male infertility is associated with GA genotype and A allele of rs6259 locus, as well as CC genotype of rs727428 locus in SHBG gene.
|
28796064 |
2017 |
|
Male infertility
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of the (TAAAA)n repeat and Asp327Asn polymorphisms in the sex hormone-binding globulin (SHBG) gene with idiopathic male infertility and relation to serum SHBG concentrations.
|
20974254 |
2011 |
|
Endometrial Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the Asp(327)Asn (rs6259) polymorphism was associated with decreased risk of endometrial cancer, particularly among postmenopausal women (OR = 0.79, 95% CI = 0.62-1.00).
|
19005973 |
2008 |
|
Malignant neoplasm of endometrium
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the Asp(327)Asn (rs6259) polymorphism was associated with decreased risk of endometrial cancer, particularly among postmenopausal women (OR = 0.79, 95% CI = 0.62-1.00).
|
19005973 |
2008 |
|
Endometrial Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene.
|
17315164 |
2007 |
|
Malignant neoplasm of endometrium
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene.
|
17315164 |
2007 |
|
Ovarian Hyperstimulation Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Compared with SHBG rs6259 TT carriers, the number of retrieved oocytes and embryo as well as the fertility rate in SHBG rs6259 GA+AA carriers was found to be decreased, while the abortion rate, incidence of ovarian hyperstimulation syndrome, transplant rejection rate, estradiol, and testosterone in serum, as well as testosterone in follicular fluid were elevated.
|
30520140 |
2019 |