|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.
|
19335934 |
2009 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke.
|
23399480 |
2013 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the BDNF Val66Met polymorphism is a relevant risk factor for geriatric depression.
|
16343697 |
2006 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression.
|
26462036 |
2015 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research.
|
17700574 |
2007 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes.
|
18205169 |
2008 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD).
|
21692988 |
2011 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A genetic variant (rs6265) of the brain-derived neurotrophic factor (BDNF) impacting on emotion processing is known to increase the risk for depression.
|
25998702 |
2015 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies.
|
20667416 |
2011 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression.
|
25648279 |
2015 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing.
|
18347599 |
2008 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history.
|
23880378 |
2013 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism may modify the association between stroke and depression.
|
17222482 |
2008 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, BDNF rs7103411 and rs6265 similarly predicted worse treatment response over 6 wk in clinical subtypes of depression such as melancholic depression only (rs7103411: TT < CC, p = 0.003; rs6265: GG < AA, p = 0.001).
|
19236730 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.
|
22931410 |
2012 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety.
|
25618300 |
2015 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to examine the chronic stress × BDNF Val66Met</span> interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet.
|
29734099 |
2018 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression.
|
22033217 |
2012 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in d</span>epression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206.
|
21215389 |
2011 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels.
|
22883353 |
2012 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect.
|
29102837 |
2018 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained.
|
17482146 |
2007 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord.
|
20921572 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
|
30664620 |
2019 |