|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms might predict the incidence of depression with ABB.
|
24274373 |
2013 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to evaluate the associations between rs6265 and poststroke depression, especially in Caucasians, with large sample size.
|
29449128 |
2018 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
|
26393465 |
2015 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the effect of seasonality and rs6265 genotype on depression outcome and brain-derived neurotrophic factor (BDNF) level with dermatitis patients from onset through remission.
|
27409526 |
2017 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
|
21037213 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.
|
21996278 |
2012 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
|
17941097 |
2008 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.
|
18263664 |
2008 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression.
|
23303061 |
2013 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.
|
20220593 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005).
|
17632285 |
2007 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression.
|
20728877 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT.
|
29802070 |
2019 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders.
|
20515664 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase).
|
20163778 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects.
|
14673216 |
2003 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met genotype and 6-month remission rates in late-life depression.
|
20195291 |
2011 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
|
28527683 |
2017 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03).
|
24433458 |
2014 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.
|
19153574 |
2009 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
|
29535036 |
2019 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history.
|
25347540 |
2014 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity.
|
18721847 |
2008 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Higher order interaction effects involving BDNF Val(66)Met, 5-HTTLPR and childhood adversity may contribute to the etiology of depressive illness.
|
17579366 |
2008 |