|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC.
|
30904785 |
2019 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing.
|
18347599 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
No differences in whole blood BDNF was seen in relation to the BDNF Val66Met polymorphism and no significant correlations between whole blood BDNF and HAMD-17 or BDI 21 scores were found.
|
23684538 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders.
|
20515664 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression.
|
22033217 |
2012 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to examine the chronic stress × BDNF Val66Met</span> interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet.
|
29734099 |
2018 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to evaluate the associations between rs6265 and poststroke depression, especially in Caucasians, with large sample size.
|
29449128 |
2018 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
|
21037213 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression.
|
17959306 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, BDNF rs7103411 and rs6265 similarly predicted worse treatment response over 6 wk in clinical subtypes of depression such as melancholic depression only (rs7103411: TT < CC, p = 0.003; rs6265: GG < AA, p = 0.001).
|
19236730 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
A genetic variant (rs6265) of the brain-derived neurotrophic factor (BDNF) impacting on emotion processing is known to increase the risk for depression.
|
25998702 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression.
|
23303061 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord.
|
20921572 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research.
|
17700574 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met genotype and 6-month remission rates in late-life depression.
|
20195291 |
2011 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
|
17911362 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
|
26393465 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three single-nucleotide polymorphisms (rs6265, rs7103411 and rs908867) were also found to modify the association between depression and promoter I methylation.
|
26285129 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the BDNF Val66Met polymorphism is a relevant risk factor for geriatric depression.
|
16343697 |
2006 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
|
29331787 |
2018 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms.
|
27852165 |
2017 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.
|
20220593 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects.
|
23968401 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects.
|
14673216 |
2003 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression.
|
24745471 |
2014 |