This case-control study highlights that <i>LEP</i> rs7799039 A>G and rs2167270 G>A polymorphisms increase the susceptibility to HCC; however, <i>LEPR</i> rs6588147 G>A polymorphism may be a protective factor for HCC in Eastern Chinese Han population.
In the stratified analyses, <i>LEPR</i> rs6588147 G>A polymorphism increased the risk of ESCC (<63 years subgroup: AA vs. GG: adjusted OR=2.58, 95%CI=1.00-6.62, <i>P</i>=0.049 and AA vs. GA/GG: adjusted OR=2.71, 95%CI=1.06-6.91, <i>P</i>=0.038; male subgroup: AA vs. GG: adjusted OR=2.19, 95%CI=1.02-4.67, <i>P</i>=0.044 and AA vs. GA/GG: adjusted OR=2.26, 95%CI=1.06-4.80, <i>P</i>=0.035).
We observed a slight reduction in colon cancer risk with the AA LEP rs2167270 genotype (OR 0.79 95% CI 0.64, 0.98) and although not reaching statistical significance, with the combined GG LEP rs2167270 and GG LEPR rs6588147 (OR 0.70, 95% CI 0.49, 1.02) genotypes.
We observed a slight reduction in colon cancer risk with the AA LEP rs2167270 genotype (OR 0.79 95% CI 0.64, 0.98) and although not reaching statistical significance, with the combined GG LEP rs2167270 and GG LEPR rs6588147 (OR 0.70, 95% CI 0.49, 1.02) genotypes.