|
Heart failure with preserved ejection fraction [HFpEF]
|
|
0.010 |
GeneticVariation
|
BEFREE |
ALDH2 rs671 polymorphism and the risk of heart failure with preserved ejection fraction (HFpEF) in patients with cardiovascular diseases.
|
30846829 |
2020 |
|
Female Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Lys/Lys genotype of rs671 was associated with increased BC risk (OR = 1.16, 95% CI 1.03-1.30, p = 0.014).
|
31066241 |
2019 |
|
Sleep Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to the genotypes of rs671, the patients were assessed with the PD sleep scale-2nd version (PDSS-2) and the Epworth sleepiness scale (ESS) for symptoms of daytime and nocturnal sleep disturbances.
|
31831791 |
2019 |
|
Hyperuricemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both rs671 major G allele and wGRS were not associated with hyperuricemia.
|
31338989 |
2019 |
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Male, rs1229984, rs671, alcohol consumption (> 20 g/day), smoking, and multiple Lugol-voiding lesions (LVLs) significantly affected the incidence of multiple metachronous SCCs.
|
30173282 |
2019 |
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to the genotypes of rs671, the patients were assessed with the PD sleep scale-2nd version (PDSS-2) and the Epworth sleepiness scale (ESS) for symptoms of daytime and nocturnal sleep disturbances.
|
31831791 |
2019 |
|
Liver diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
To elucidate associations among liver disease, lipid profile, body mass index (BMI), ketonuria, and meal skipping under the influence of alcohol dehydrogenase-1B (ADH1B; rs1229984) and aldehyde dehydrogenase-2 (ALDH2; rs671) genotypes in men with alcohol dependence.
|
31845443 |
2019 |
|
Congenital Abnormality
|
|
0.010 |
GeneticVariation
|
BEFREE |
Despite the role of aldehyde dehydrogenase 2 (ALDH2) in the detoxification of endogenous aldehydes, the defective polymorphism (rs671), which is highly prevalent among East Asians, does not show a serious phenotype, such as congenital abnormality.
|
31368098 |
2019 |
|
Middle insomnia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The patients with rs671 (A) reported a trend toward more frequent difficulty staying asleep than the patients with rs671 (GG).(F = 3.278, p = 0.074).
|
31831791 |
2019 |
|
Malignant neoplasm of female breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Lys/Lys genotype of rs671 was associated with increased BC risk (OR = 1.16, 95% CI 1.03-1.30, p = 0.014).
|
31066241 |
2019 |
|
Sleep disturbances
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to the genotypes of rs671, the patients were assessed with the PD sleep scale-2nd version (PDSS-2) and the Epworth sleepiness scale (ESS) for symptoms of daytime and nocturnal sleep disturbances.
|
31831791 |
2019 |
|
Adrenoleukodystrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The prevalence of the common form of the single nucleotide polymorphism rs671, 504glu (glu/glu) was significantly higher in patients with ALD (95.4%) compared to that of controls (73.7%, P < 0.0001).
|
29779728 |
2018 |
|
Hypo HDL cholesterolaemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In logistic regression analysis, rs671 A allele homozygote carriers have 2.65 times higher risk of developing hypo-HDL cholesterolemia than G allele homozygote carriers.
|
30334266 |
2018 |
|
Prolapsed lumbar disc
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the allele model analysis, we found the frequency of the "A" allele of rs671 was significantly higher in LDH cases than in controls (OR = 1.414, 95%CI: 1.109-1.803, P = 0.005).
|
30166580 |
2018 |
|
Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
Alcoholic Liver Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease.
|
29779728 |
2018 |
|
Fatty Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype.
|
29247577 |
2018 |
|
ovarian neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype.
|
29247577 |
2018 |
|
Squamous cell carcinoma of the hypopharynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped ADH1B (rs1229984) and ALDH2 (rs671) single nucleotide polymorphisms (SNPs) in 85 Japanese male patients with hypopharyngeal SCC.
|
29286190 |
2018 |
|
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype.
|
29247577 |
2018 |
|
Drug Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the genetic model analysis, we found that rs671 is associated with an increased risk of drug addiction under additive, dominant and recessive models (p < 0.001), while rs886205, rs441 and rs4646778 displayed a decreased drug addiction risk under additive and recessive model, respectively (p < 0.05).
|
28052001 |
2017 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
To investigate the neural mechanism linking Glu504Lys to schizophrenia, we calculated the functional connectivity (FC) and applied an imaging genetics strategy using resting-state fMRI data.
|
26941382 |
2017 |
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant relation was found between ALDH2 rs671 and DR.
|
28208752 |
2017 |
|
Cerebral Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
CONCLUSIONS ALDH2 Glu504Lys could be a risk factor for collateral circulation and a negative predictor for short-term prognosis in acute cerebral infarction in Han Chinese.
|
28939800 |
2017 |