|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is an established genetic risk of hypertension, diabetes, and coronary heart diseases in Asian population.
|
30846829 |
2020 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings demonstrate that these variants, which were highly linked with ALDH2 rs671 and ADH1B rs1229984, were significant modulators for AD in our Han Chinese cohort.
|
31591379 |
2019 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism.
|
28610454 |
2018 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Six common variants at ALDH2 gene, including rs2339840, rs4648328, rs4767939, rs11066028, rs16941669, and rs671, were selected to test the associations of those polymorphisms with the cardiovascular outcome in patients with CHD after PCI.
|
29742731 |
2018 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coronary artery disease risk in a Chinese Han population with dyslipidemia: A guide to targeted heart health management.
|
29960587 |
2018 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among northeast Asians, the variant aldehyde dehydrogenase allele, ALDH2*2 (rs671, A/G, minor/major), has been inversely associated with alcohol dependence.
|
28728635 |
2017 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
ALDH2 rs671 polymorphism is proven to be closely related to the prevalence of CAD, hypertension, diabetes mellitus and alcoholism, which are etiological factors of heart failure.
|
27742538 |
2017 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for coronary disease.
|
27191745 |
2016 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample.
|
25372623 |
2015 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped rs671 of ALDH2 in 96 coronary heart disease (CHD) patients with four methods including high resolution melting analysis (HRM), TaqMan allelic discrimination assay (TaqMan), allele-specific PCR (AS-PCR) and pyrosequencing.
|
25803854 |
2015 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
GWASDB |
When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.
|
24277619 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism.
|
23969552 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.
|
24277619 |
2014 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association between the aldehyde dehydrogenase 2 (ALDH2, rs671) genotypes and the estimated glomerular filtration rate (eGFR) was investigated in Japanese hypertensive patients with/without coronary artery disease or with ischemic heart failure (HF), and age/sex-matched normotensive healthy controls.
|
24067347 |
2014 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: a meta-analysis.
|
24333098 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.
|
24277619 |
2014 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.
|
25263942 |
2014 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis results showed that the A variant of the ALDH2 rs671 polymorphism may be associated with increase risks of CHD (odds ratios [OR]=1.36, 95% confidence interval [CI]=1.06-1.75, p=0.017) and MI (OR=1.64, 95% CI=1.22-2.20, p=0.001).
|
23697560 |
2013 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Individuals heterozygous or homozygous for the lys (A or *2) allele at the single nucleotide polymorphism (SNP) glu504lys (rs671) of ALDH2 have greatly reduced ability to metabolize acetaldehyde, which greatly decreases their risk for alcohol dependence (AD).
|
22102315 |
2012 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of coronary artery disease in the Japanese.
|
21971053 |
2012 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary artery disease in the Japanese.
|
21971053 |
2012 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population.
|
20180859 |
2010 |
|
Coronary heart disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.
|
20417517 |
2010 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Data presented show that antialcohol drugs that inhibit Aldh2 gene expression can be generated endogenously in liver cells infected by an adenoviral vector carrying an antisense-coding gene, thus mimicking the high-acetaldehyde phenotype that exists in humans carrying the Glu487Lys mutation who are protected against alcoholism.
|
16131845 |
2005 |