|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.
|
26148204 |
2015 |
|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.
|
23371916 |
2013 |
|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.
|
23371916 |
2013 |
|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.
|
23642732 |
2013 |
|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
UGT1A1 is a major locus influencing bilirubin levels in African Americans.
|
22085899 |
2012 |
|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association of serum bilirubin levels in Korean population.
|
20639394 |
2010 |
|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association meta-analysis for total serum bilirubin levels.
|
19414484 |
2009 |
|
Bilirubin measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association meta-analysis for total serum bilirubin levels.
|
19414484 |
2009 |
|
HIV Infections
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.
|
26148204 |
2015 |
|
Bilirubin level result
|
|
0.700 |
GeneticVariation
|
GWASDB |
Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.
|
23642732 |
2013 |
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide assessment of variability in human serum metabolism.
|
23281178 |
2013 |
|
Bilirubin level result
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.
|
23371916 |
2013 |
|
Bilirubin level result
|
|
0.700 |
GeneticVariation
|
GWASDB |
UGT1A1 is a major locus influencing bilirubin levels in African Americans.
|
22085899 |
2012 |
|
Bilirubin level result
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association meta-analysis for total serum bilirubin levels.
|
19414484 |
2009 |
|
BILIRUBIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1
|
|
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The effects of gender and uridine diphosphate-glycosytransferase 1A1 (UGT1A1) genetic polymorphisms (rs4124874, rs4148323, and rs6742078) on telmisartan plasma concentration and blood pressure in Chinese patients with hypertension have been reported previously.
|
31254178 |
2019 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
A genetic variant at the UGT1A1*28 locus consistently shown to be strongly associated with circulating bilirubin levels-rs6742078-was not significantly associated with blood pressure or hypertension (<i>P</i>>0.05 for all), arguing against a strong causal association of circulating bilirubin with blood pressure.
|
29133521 |
2017 |
|
Cholelithiasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Second, taking advantage of mendelian randomization, we tested whether a genetic variant in the bilirubin glucoronidating enzyme UGT1A1 (rs6742078) was associated with increased plasma bilirubin levels and, in turn, with an increased risk of symptomatic gallstone disease.
|
23753274 |
2013 |
|
Cholelithiasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The UGT1A1 Gilbert syndrome variant rs6742078 is associated with gallstone disease in men; further studies are required regarding the sex-specific physiology of bilirubin and bile acid metabolism.
|
20837016 |
2010 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
The 14 single-nucleotide polymorphisms (SNPs) (<10<sup>-7</sup>) including rs6742078 of uridine diphosphoglucuronyl-transferase were selected from genome-wide association study of bilirubin level in the KCPS-II (Korean Cancer Prevention Study-II) Biobank subcohort consisting of 4793 healthy Korean and 806 stroke cases.
|
28389615 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
In adjusted analyses, rs6742078, which explained 19.5% of bilirubin variation, was strongly associated with total bilirubin (a 0.68-SD increase in bilirubin levels per T allele; P < 1 × 10(-122)) and was also associated with T2D risk (odds ratio [OR] 0.69 [95% CI 0.54-0.90]; P = 0.006).
|
25368098 |
2015 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
UGT1A1 rs6742078 TT versus GG genotype was associated with 95% increased bilirubin levels (P < 0.001); TT versus GG genotype was associated with odds ratios (ORs) of 1.03 (95% CI, 0.96-1.11; P = 0.73) for IHD and 1.01 (95% CI, 0.92-1.12; P = 0.68) for MI.
|
22805420 |
2013 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
UGT1A1 rs6742078 TT versus GG genotype was associated with 95% increased bilirubin levels (P < 0.001); TT versus GG genotype was associated with odds ratios (ORs) of 1.03 (95% CI, 0.96-1.11; P = 0.73) for IHD and 1.01 (95% CI, 0.92-1.12; P = 0.68) for MI.
|
22805420 |
2013 |
|
Gilbert Disease (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The UGT1A1 Gilbert syndrome variant rs6742078 is associated with gallstone disease in men; further studies are required regarding the sex-specific physiology of bilirubin and bile acid metabolism.
|
20837016 |
2010 |
|
Cholecystolithiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
UGT1A1 (rs6742078; P = .018) was associated with overall gallstone</span> risk.
|
20837016 |
2010 |