|
Disorder of Achilles tendon
|
|
0.030 |
GeneticVariation
|
BEFREE |
Two SNPs, rs679620 (OR=0.82, P=0.0006, MMP3) and rs4789932 (OR=1.2, P=0.0002, TIMP2) were identified to be significantly associated with chronic AT risk.
|
31208828 |
2019 |
|
Disorder of Achilles tendon
|
|
0.030 |
GeneticVariation
|
BEFREE |
Based on high linkage with the previously associated MMP3 variant rs679620, rs3025058 was inferred and found to be associated with increased risk for Achilles tendinopathy within the South African group (P = 0.012; OR: 2.88; 95% CI: 1.4 to 6.1).
|
27211292 |
2017 |
|
Disorder of Achilles tendon
|
|
0.030 |
GeneticVariation
|
BEFREE |
As single markers, significant associations were found between the GG genotype of rs679620 (OR = 2.5, 95% CI 1.2 to 4.90, p = 0.010), the CC genotype of rs591058 (OR = 2.3, 95% CI 1.1 to 4.50, p = 0.023) and the AA genotype of rs650108 (OR = 4.9, 95% CI 1.0 to 24.1, p = 0.043) and risk of Achilles tendinopathy.
|
19042922 |
2009 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our findings indicate that the rs679620 A allele carriers have increased risk of ischemic stroke in Asians, but there is no association between rs3025058 and ischemic stroke risk.
|
29440903 |
2018 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although results thus far are inconsistent, meta-analysis has demonstrated that MMP-3 Glu45Lys and MMP-9 1562C/T gene polymorphisms were associated with CAD risk.
|
24938016 |
2014 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The probability of having hypertension was significant for rs3025058 under the additive (odds ratio; 95% confidence interval; P: 1.33; 1.16-1.53; <0.001) and dominant (1.43; 1.18-1.73; <0.001) models and was significant for rs679620 under the additive (1.27; 1.1-1.46; <0.001) model after adjusting for confounders.
|
24830539 |
2014 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke.
|
20622166 |
2010 |
|
Chronic Kidney Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
The chi-square test and multivariable logistic regression analysis with adjustment for covariates revealed that the -219G-->T polymorphism of APOE, the -519A-->G of MMP1, the -866G-->A of UCP2, the -1607/1G-->2G of MMP1, the A-->G (Lys45Glu) of MMP3, the G-->A (Ala163Thr) of AGTR1, the G-->A (Gly670Arg) of PECAM1, and the -55C-->T of UCP3 were significantly (false discovery rate <0.05) associated with CKD.
|
19406964 |
2009 |
|
Chronic Kidney Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that ten different polymorphisms were associated (P<0.05) with the prevalence of CKD in high- or low-risk subjects: the -519Aright curved arrow G polymorphism of MMP1, the 1061Aright curved arrow G (Ile405Val) polymorphism of CETP, the Aright curved arrow G (Lys45Glu) polymorphism of MMP3, the -219Gright curved arrow T polymorphism of APOE, the Aright curved arrow G (Ile1205Val) polymorphism of COL3A1, the -863Cright curved arrow A polymorphism of TNF, and the 1454Cright curved arrow G (Leu125Val) polymorphism of PECAM1 in high-risk subjects; and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2, the 2386Aright curved arrow G (Ile796Val) polymorphism of SCAP, and the TAAAright curved arrow del polymorphism of PDE4D in low-risk subjects.
|
19424605 |
2009 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Interactions between metallopeptidase 3 polymorphism rs679620 and BMI in predicting blood pressure in African-American women with hypertension.
|
19008710 |
2008 |
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
MMP-3 (-1171) 5A/6A and Lys45Glu (A/G) polymorphisms were associated with the decline of lung function among COPD patients.
|
29165854 |
2018 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The impact of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G variants and plasma MMP levels on obesity and microvascular reactivity in Tunisians.
|
29317790 |
2017 |
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that rs639752 (dominant, OR = 2.03, 95% CI: 1.03-4.01, <i>P</i> = 0.038; over-dominant, OR = 2.00, 95% CI: 1.03-3.88, <i>P</i> = 0.037); rs520540 (dominant, OR = 2.03, 95% CI: 1.03-4.01, <i>P</i> = 0.038; over-dominant, OR = 2.00, 95% CI: 1.03-3.88, <i>P</i> = 0.037); rs602128 (dominant, OR = 2.03, 95% CI: 1.03-4.01, <i>P</i> = 0.038; over-dominant, OR = 2.01, 95% CI: 1.03-3.89, <i>P</i> = 0.037); and rs679620 (dominant, OR = 2.03, 95% CI: 1.03-4.01, <i>P</i> = 0.038; over-dominant, OR = 2.04, 95% CI: 1.05-3.96, <i>P</i> = 0.033) were associated with the increased risk of OA.
|
29108328 |
2017 |
|
Carpal Tunnel Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Ninety-seven, self-reported Coloured participants with a history of CTS release surgery and 131 appropriately matched controls were genotyped for MMP10 rs486055 (C/T), MMP1 rs1799750 (G/GG), MMP3 rs679620 (A/G) or MMP12 rs2276109 (A/G) variants.
|
26521080 |
2016 |
|
Caries (morphologic abnormality)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyse MMP2 (rs2287074) and MMP3 (rs679620) single nucleotide polymorphisms (SNPs) and their role in caries susceptibility.
|
27043485 |
2016 |
|
Dental caries
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, as dental caries is a multifactorial disorder and several genes are likely to have influence on it, it is reasonable to expect that SNPs, even those proven to be functional like rs679620, potentially play a significant, but not major role in the disease outcome.
|
27043485 |
2016 |
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TIMP1 showed association with chronic periodontitis in the Brazilian population (for rs5906435, p = 0.0004), whereas MMP3 showed association in the US population (for rs679620, p = 0.0003; and rs650108, p = 0.002) and in the Brazilian population (for rs639752, p = 0.005).
|
22671570 |
2012 |
|
Disorder of tendon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the MMP3 gene variant rs679620 and the COL5A1 marker rs12722 interact to modify the risk of tendinopathy.
|
19042922 |
2009 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the occurrence of the -1612 5A/6A, -376C/G, and Glu45Lys polymorphisms of MMP3 and the -1562C/T and R279Q polymorphisms of MMP9 and their relation to the risk of coronary heart disease (CHD; stenosis >/=50% of the diameter in at least one major coronary artery) in a Chinese Han population.
|
19438845 |
2009 |
|
Tendinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the MMP3 gene variant rs679620 and the COL5A1 marker rs12722 interact to modify the risk of tendinopathy.
|
19042922 |
2009 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphisms of MMP-3; 5A/6A insertion polymorphism in the promoter, rs3025079, rs520540 and rs679620 also did not influence risk for AD.
|
15748780 |
2005 |