|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
The aim of this meta-analysis was to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601C/T, insulin [INS] rs689A/T and transcription factor 7-like 2 [TCF7L2] rs7903146C/T) with latent autoimmune diabetes in adults (LADA).
|
30456822 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
GWASCAT |
Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study.
|
31152121 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
The adenine at rs689 is strongly associated with type 1 diabetes.
|
31150930 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
In this work we show that the analysis of non-HLA related to type 1 diabetes in the INS-VNTR, SNP rs689, and rs3842753 improves the identification of these patients.
|
26273670 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
A gene-gene interaction in the T1D data were observed between the IL2RA rs2104286 and GIMAP4 rs9640279 (OR 1.52, p = 0.0064) and indicated between INS rs689 and GIMAP5 rs2286899.
|
25964488 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
INS gene polymorphism rs689 and IKZF4 polymorphism (rs1701704) were strongly associated with IAA positivity at the time of T1D diagnosis (p = 0.000004 and 0.00044, respectively).
|
23721563 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
The methylation of CpG -69, -102, -180, -206, but not CpG -19, -135, -234 was strongly influenced by the cis-genotype at rs689, a SNP known to show a strong association with T1D.
|
22567146 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.790 |
GeneticVariation
|
BEFREE |
In addition, rs689 was associated with age-at-diagnosis of T1D (P=0.001), with homozygosity for the T1D protective T allele, delaying the onset of T1D by approximately 2 years in these families.
|
19956106 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.720 |
GeneticVariation
|
BEFREE |
The rs2476601C/T, rs689A/T, and rs7903146C/T polymorphisms were found to be associated with the risk of LADA, thereby indicating that, genetically, LADA could be an admixture of both T1D and T2D.
|
30456822 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.720 |
GeneticVariation
|
GWASCAT |
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.
|
30254083 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.720 |
GeneticVariation
|
BEFREE |
The analyses revealed that INS (rs689) polymorphism conferred risk towards T2D susceptibility in all the three ethnic groups whereas INSR (rs1799816) polymorphism conferred risk towards T2D in Brahmins only and PP1G.G (rs1799999) polymorphism indicated T2D risk in Jat Sikhs only.
|
26251103 |
2016 |
|
Latent Autoimmune Diabetes in Adults
|
|
0.710 |
GeneticVariation
|
BEFREE |
The aim of this meta-analysis was to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601C/T, insulin [INS] rs689A/T and transcription factor 7-like 2 [TCF7L2] rs7903146C/T) with latent autoimmune diabetes in adults (LADA).
|
30456822 |
2019 |
|
Latent Autoimmune Diabetes in Adults
|
|
0.710 |
GeneticVariation
|
GWASCAT |
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.
|
30254083 |
2018 |
|
Autoantibody measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Latent autoimmune diabetes mellitus in adult
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs2476601C/T, rs689A/T, and rs7903146C/T polymorphisms were found to be associated with the risk of LADA, thereby indicating that, genetically, LADA could be an admixture of both T1D and T2D.
|
30456822 |
2019 |
|
Latent autoimmune diabetes mellitus in adult
|
|
0.020 |
GeneticVariation
|
BEFREE |
The AA genotype of rs689, referring to the class I allele in the INS VNTR, as well as the CT/TT genotypes of rs2476601 in the PTPN22 gene, were increased both in type 1 diabetic (P = 3 x 10(-14) and P = 1 x 10(-10), respectively) and LADA (P = 0.001 and P = 0.002) subjects compared with control subjects.
|
18310307 |
2008 |
|
Adenocarcinoma of the gastroesophageal junction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings highlight that TCF7L2 rs290481, INS rs689, and INSR rs1799817 polymorphisms may increase the risk of AEG.
|
31211453 |
2019 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Statistical analysis allowed observation of the association of the SNP rs3842748, through its GC genotype, with obesity in PCOS (P = 0.049; OR CI95% 1,59 [1.00-2.51]) and in classical PCOS (YPCOS) (P = 0.010), as well as the correlation of the SNP rs689 and the pair of haplotypes h1/h1 with higher levels of testosteronaemia in the PCOS group, although this was at the limit of significance (P = 0.054) CONCLUSION: These results are in accordance with some studies in literature and highlight the role of insulin gene VNTR in complex metabolic disorders.
|
26136127 |
2015 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Statistical analysis allowed observation of the association of the SNP rs3842748, through its GC genotype, with obesity in PCOS (P = 0.049; OR CI95% 1,59 [1.00-2.51]) and in classical PCOS (YPCOS) (P = 0.010), as well as the correlation of the SNP rs689 and the pair of haplotypes h1/h1 with higher levels of testosteronaemia in the PCOS group, although this was at the limit of significance (P = 0.054) CONCLUSION: These results are in accordance with some studies in literature and highlight the role of insulin gene VNTR in complex metabolic disorders.
|
26136127 |
2015 |
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |