rs6903608, HLA-DRB9

N. diseases: 11
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hodgkin Disease
CUI: C0019829
Disease: Hodgkin Disease
0.800 GeneticVariation GWASCAT A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. 24920014 2014
Hodgkin Disease
CUI: C0019829
Disease: Hodgkin Disease
0.800 GeneticVariation GWASDB A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. 24920014 2014
Hodgkin Disease
CUI: C0019829
Disease: Hodgkin Disease
0.800 GeneticVariation GWASCAT Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. 24149102 2013
Hodgkin Disease
CUI: C0019829
Disease: Hodgkin Disease
0.800 GeneticVariation GWASDB Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. 24149102 2013
Hodgkin Disease
CUI: C0019829
Disease: Hodgkin Disease
0.800 GeneticVariation GWASDB Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. 22286212 2012
Hodgkin Disease
CUI: C0019829
Disease: Hodgkin Disease
0.800 GeneticVariation GWASDB A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). 21037568 2010
Hodgkin Disease
CUI: C0019829
Disease: Hodgkin Disease
0.800 GeneticVariation GWASCAT A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). 21037568 2010
Nodular Sclerosis Classical Hodgkin Lymphoma
0.710 GeneticVariation GWASCAT These SNPs are found on 2 haplotypes associated with NSHL risk (rs204999-rs9268528-rs9268542-rs6903608-rs2858870; AGGCT, OR = 1.7, P = 1.71 × 10(-6); GAATC, OR = 0.4, P = 1.16 × 10(-4)). 22086417 2012
Nodular Sclerosis Classical Hodgkin Lymphoma
0.710 GeneticVariation BEFREE These SNPs are found on 2 haplotypes associated with NSHL risk (rs204999-rs9268528-rs9268542-rs6903608-rs2858870; AGGCT, OR = 1.7, P = 1.71 × 10(-6); GAATC, OR = 0.4, P = 1.16 × 10(-4)). 22086417 2012
Nodular Sclerosis Classical Hodgkin Lymphoma
0.710 GeneticVariation GWASCAT These SNPs are found on 2 haplotypes associated with NSHL risk (rs204999-rs9268528-rs9268542-rs6903608-rs2858870; AGGCT, OR = 1.7, P = 1.71 × 10(-6); GAATC, OR = 0.4, P = 1.16 × 10(-4)). 22086417 2012
Graves Disease
CUI: C0018213
Disease: Graves Disease
0.700 GeneticVariation GWASDB A genome-wide association study identifies two new risk loci for Graves' disease. 21841780 2011
Rheumatoid Arthritis
CUI: C0003873
Disease: Rheumatoid Arthritis
0.700 GeneticVariation GWASDB A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. 21156761 2011
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.700 GeneticVariation GWASDB Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. 20598377 2010
Rheumatoid Arthritis
CUI: C0003873
Disease: Rheumatoid Arthritis
0.700 GeneticVariation GWASDB REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. 19503088 2009
Rheumatoid Arthritis
CUI: C0003873
Disease: Rheumatoid Arthritis
0.700 GeneticVariation GWASDB TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. 17804836 2007
Diabetes Mellitus, Insulin-Dependent
0.700 GeneticVariation GWASDB A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. 17632545 2007
Adult Classical Hodgkin Lymphoma
CUI: C2347747
Disease: Adult Classical Hodgkin Lymphoma
0.020 GeneticVariation BEFREE For EBV-negative cHL the class II SNP rs6903608 remained the strongest predictor of disease risk after adjusting for the effects of common HLA alleles. 25648508 2015
Classical Hodgkin's Lymphoma
CUI: C1333064
Disease: Classical Hodgkin's Lymphoma
0.020 GeneticVariation BEFREE For EBV-negative cHL the class II SNP rs6903608 remained the strongest predictor of disease risk after adjusting for the effects of common HLA alleles. 25648508 2015
Classical Hodgkin's Lymphoma
CUI: C1333064
Disease: Classical Hodgkin's Lymphoma
0.020 GeneticVariation BEFREE The association between rs6903608 and EBV-negative cHL was confined to the nodular sclerosis histological subtype. 22286212 2012
Adult Classical Hodgkin Lymphoma
CUI: C2347747
Disease: Adult Classical Hodgkin Lymphoma
0.020 GeneticVariation BEFREE The association between rs6903608 and EBV-negative cHL was confined to the nodular sclerosis histological subtype. 22286212 2012
Thrombotic thrombocytopenic purpura, acquired
0.010 GeneticVariation BEFREE Results and conclusion We identified one common variant (rs6903608</span>) located within the HLA class II locus that was independently associated with acquired TTP at genome-wide significance and conferred a 2.6-fold increased risk of developing a TTP episode (95% confidence interval [CI] 2.02-3.27, P = 1.64 × 10<sup>-14</sup> ). 27762046 2016
Congenital Thrombotic Thrombocytopenic Purpura
0.010 GeneticVariation BEFREE Results and conclusion We identified one common variant (rs6903608) located within the HLA class II locus that was independently associated with acquired TTP at genome-wide significance and conferred a 2.6-fold increased risk of developing a TTP episode (95% confidence interval [CI] 2.02-3.27, P = 1.64 × 10<sup>-14</sup> ). 27762046 2016
Purpura, Thrombotic Thrombocytopenic
0.010 GeneticVariation BEFREE Results and conclusion We identified one common variant (rs6903608) located within the HLA class II locus that was independently associated with acquired TTP at genome-wide significance and conferred a 2.6-fold increased risk of developing a TTP episode (95% confidence interval [CI] 2.02-3.27, P = 1.64 × 10<sup>-14</sup> ). 27762046 2016