|
Coronary heart disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease patients.
|
24618918 |
2014 |
|
Coronary heart disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
|
21804106 |
2012 |
|
Coronary heart disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)).
|
22042884 |
2011 |
|
Coronary heart disease
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
|
Coronary heart disease
|
|
0.830 |
GeneticVariation
|
GWASCAT |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation
|
BEFREE |
One of them is the marker rs6922269, which has been suggested as a risk factor for development of MI in Western populations.
|
25809277 |
2015 |
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation
|
BEFREE |
No association for MI or lipid levels was found for SNPs rs2943634 and rs6922269 (P-adj > 0.05).
|
21463265 |
2011 |
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation
|
BEFREE |
One marker, rs6922269, in MTHFD1L was significantly protective against MI (OR=0.68, p=0.0035), while the variant rs4977574 in CDKN2A-CDKN2B was significantly associated with MI (OR=1.33, p=0.0086).
|
22216278 |
2011 |
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of the present case-control study including 324 healthy controls and 296 patients with coronary heart disease from Tunisia, was to assess relation between three polymorphisms previously reported to be strongly associated with coronary heart disease in the Welcome Trust Case Control Consortium (WTCCC) and the German myocardial infarction family studies: locus 9p21.3 (rs 1333049), locus 6q25.1 (rs6922269) and 2q36.3 (rs2943634).
|
19373437 |
2010 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
We conclude, that rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS.
|
25809277 |
2015 |
|
Acute Coronary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
We analyzed the relationship between rs6922269 variant on MTHFD1L gene and (i) risk of the acute coronary syndrome (ACS) in the Czech population and (ii) mortality in 7 years follow up.
|
25809277 |
2015 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart disease patients.
|
24618918 |
2014 |
|
Acute Coronary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients.
|
24618918 |
2014 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Polymorphisms in MTHFD1L, including rs6922269</span>, have been implicated in risk for coronary artery disease (CAD).
|
24618918 |
2014 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
After Cox adjustment for other ACS risk factors, of 95 SNPs tested in 811 whites only the association with the rs6922269 in MTHFD1L was statistically significant, with a 2.6-fold mortality hazard (P = 0.007).
|
21957892 |
2011 |
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Variant rs6922269 in neither cohort was significantly associated with CAD.
|
19135198 |
2009 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
In contrast, variant rs6922269 did not show any impact on coronary atherosclerosis.
|
19135198 |
2009 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, rs6922269 polymorphism was not associated with the classical risk factors (dyslipidemia, hypertension, obesity, smoking, diabetes) in control population.
|
25809277 |
2015 |