|
METABOLIC SYNDROME, SUSCEPTIBILITY TO
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
OBESITY, AGE AT ONSET OF
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
MTLRP genetic polymorphism (214C>A) was associated with Type 2 diabetes in Caucasian population: a meta-analysis.
|
25095788 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The GHRL Leu72Met polymorphism may help to maintain normal renal function and may protect against the development of DN by reducing albuminuria and improving renal function in Chinese patients with type 2 diabetes.
|
24132517 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The Leu72Met polymorphism of the preproghrelin gene was not associated with T2DM in Chinese population.
|
22441120 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Recent studies have shown that the preproghrelin Leu72Met polymorphism is associated with serum creatinine (Scr) concentration in type 2 diabetes; 72Met carriers exhibited lower Scr levels as compared with the 72Met non-carriers.
|
16793966 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our data indicate that the preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus.
|
16483881 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The Leu72Met polymorphism of the preproghrelin gene was not related to cardiovascular disease in type 2 diabetes mellitus patients.
|
12974878 |
2003 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
Average dietary energy in lunch, rs3782886, and rs696217 were associated with obesity, and rs3782886 was associated with other metabolic abnormalities.
|
27245511 |
2019 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism.
|
23257630 |
2013 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes.
|
22441120 |
2012 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome.
|
17884032 |
2008 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children.
|
16459454 |
2005 |
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
The GHRL Leu72Met polymorphism may help to maintain normal renal function and may protect against the development of DN by reducing albuminuria and improving renal function in Chinese patients with type 2 diabetes.
|
24132517 |
2014 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes.
|
22441120 |
2012 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes.
|
22441120 |
2012 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome.
|
17884032 |
2008 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu72Met polymorphism was not associated with hypertension, diabetes, dyslipidemia, the number of diseased vessels, plasma total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol or fasting glucose levels in CAD patients.
|
17884032 |
2008 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
The frequency of the Leu72Met polymorphism in diabetic nephropathy was significantly lower in patients with renal dysfunction (15.9%, P < 0.01) than in patients with normal renal function (42.0%) or in the diabetes control group (40.6%).
|
16793966 |
2006 |
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu72Met polymorphism was also associated with serum total cholesterol levels in diabetic nephropathy patients with renal dysfunction; the 72Met carriers had lower total cholesterol levels than the 72Met non-carriers (P < 0.05).
|
16793966 |
2006 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
The frequency of the Leu72Met polymorphism in diabetic nephropathy was significantly lower in patients with renal dysfunction (15.9%, P < 0.01) than in patients with normal renal function (42.0%) or in the diabetes control group (40.6%).
|
16793966 |
2006 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu72Met polymorphism was not associated with hypertension, macroangiopathy, retinopathy, serum cholesterol, triglyceride, blood urea nitrogen, HbA(1c), lipoprotein (a), fasting insulin, or 24-hour urinary protein levels in the type 2 diabetic group.
|
16483881 |
2006 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu72Met variant was also associated with increased prevalence of metabolic syndrome (23.2 vs. 13.4%; age- and sex-adjusted odds ratio = 2.57; P = 0.02) as well as higher fasting glucose, lower high-density lipoprotein, and higher triglyceride levels (P = 0.02, P = 0.007, and P = 0.04, respectively).
|
16204371 |
2005 |
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, a significant interaction effect between GHRL rs696217 and HCRTR1 rs2271933 was found to predict the PTSD Checklist (PCL-5) total score (P = 0.007).
|
30326460 |
2019 |
|
Overweight and obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The major allele of rs696217 significantly increased BMI and an increased OR with obesity, while the minor allele of rs3782886 was associated with significantly decreased AC and the decreased ORs with overweight and obesity.
|
27245511 |
2019 |