|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the T235M polymorphism in the AGT product is associated with an increased risk of essential hypertension in multiple populations, making AGT a good example of a quantitative-trait locus underlying susceptibility to a common disease.
|
11731937 |
2002 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results support the linkage of essential hypertension to the angiotensinogen locus but do not indicate a specific role for the M235T variant.
|
9314412 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether carotid artery stiffness was increased in patients with untreated essential hypertension who are homozygous for the T allele of the M235T polymorphism of the angiotensinogen (AGT) gene and in mutant mice carrying three copies of the angiotensinogen (Agt) gene.
|
15201545 |
2004 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common variant at codon 235 of the angiotensinogen gene with methionine to threonine amino acid substitution (AGT M235T) has been reported as a genetic risk for essential hypertension.
|
11230286 |
2001 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T?
|
18227406 |
2008 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two molecular variants of the angiotensinogen gene, one encoding threonine instead of methionine at position 235 (M235T) and the other encoding methionine rather than threonine at position 174 (T174M), were also tested for possible association with essential hypertension.
|
8177268 |
1994 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The molecular variant M235T, but not T174M, of the AGT gene is associated significantly with essential hypertension in this Taiwanese population.
|
9218179 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen (AGT) gene M235T variant is associated with essential hypertension and elevated plasma AGT concentrations, although the underlying mechanisms are unknown.
|
9403548 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, variation in the number of M235T alleles did not make a significant contribution to predicting the probability of having essential hypertension, either alone or in conjunction with other predictor variables.
|
7649545 |
1995 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that AGT M235T and ACE I/D modulate the risk of essential hypertension in Han Chinese population.
|
20087216 |
2010 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies in different populations link Threonine instead of methionine at position 235 (M235T) and Methinine instead of threonine at position 174 (T174M) polymorphisms with essential hypertension.
|
18404605 |
2008 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gender-related association of AGT gene variants (M235T and T174M) with essential hypertension--a case-control study.
|
22148914 |
2012 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T polymorphism of the angiotensinogen gene (AGT) is associated with an increased risk of primary hypertension, which may then lead to progressive renal disease.
|
12164881 |
2002 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our single-locus analysis revealed that except for a marginal, significant association of A-20C allele distribution, no significant association between genotype and allele distributions of the A-20C, A-6G, or M235T polymorphism of AGT and essential hypertension was found.
|
18250562 |
2007 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, we reported evidence for genetic linkage between human essential hypertension and the angiotensinogen gene (AGT) and an association with a common molecular variant of this gene (methionine 235 --> threonine or T235).
|
8728297 |
1996 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although polymorphisms in renin-angiotensin-aldosterone (RAA) system genes for angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AT1 A/C1166), and aldosterone synthase (CYP11B2-344T/C) have been major targets for genetic investigation in association with essential hypertension (EH), the influence of these genetic factors is still to be determined.
|
17190732 |
2007 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T mutation of the human angiotensinogen gene has been shown to be associated with elevated circulating angiotensinogen concentrations and essential hypertension.
|
16940224 |
2006 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Strong epistatic interactions were found between -6G>A, M235T and -217G>A markers, supporting the synergistic effect between them leading to EHT.
|
22570327 |
2012 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, if the Met235-->Thr variant of AGT is involved in essential HT, then its contribution may be, at best, much weaker in other HT groups.
|
8267622 |
1993 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study we examined the genotype frequencies of the insertion/deletion polymorphisms of the ACE gene and the M235T polymorphism of the Angiotensinogen (Agt) gene in patients with essential hypertension in comparison with normotensive subjects.
|
9524045 |
1998 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity.
|
21779803 |
2012 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
According to combined haplotype analysis of diallele and microsatellite markers, it remains a possibility that M235T, T+31C, G-6A, A-20C and G-1074T polymorphisms may play an important role in increased risk for essential hypertension.
|
11191642 |
2000 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of our study suggest an association of the M235T polymorphism in the gene encoding angiotensinogen with essential hypertension.
|
12169209 |
2003 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of a polymorphism encoding threonine instead of methionine (M235T) has been associated not only with increased plasma angiotensinogen concentration but also with essential hypertension.
|
8593944 |
1996 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects.
|
22974788 |
2012 |