|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, if the Met235-->Thr variant of AGT is involved in essential HT, then its contribution may be, at best, much weaker in other HT groups.
|
8267622 |
1993 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two molecular variants of the angiotensinogen gene, one encoding threonine instead of methionine at position 235 (M235T) and the other encoding methionine rather than threonine at position 174 (T174M), were also tested for possible association with essential hypertension.
|
8177268 |
1994 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, variation in the number of M235T alleles did not make a significant contribution to predicting the probability of having essential hypertension, either alone or in conjunction with other predictor variables.
|
7649545 |
1995 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, we reported evidence for genetic linkage between human essential hypertension and the angiotensinogen gene (AGT) and an association with a common molecular variant of this gene (methionine 235 --> threonine or T235).
|
8728297 |
1996 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of a polymorphism encoding threonine instead of methionine (M235T) has been associated not only with increased plasma angiotensinogen concentration but also with essential hypertension.
|
8593944 |
1996 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results support the linkage of essential hypertension to the angiotensinogen locus but do not indicate a specific role for the M235T variant.
|
9314412 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The molecular variant M235T, but not T174M, of the AGT gene is associated significantly with essential hypertension in this Taiwanese population.
|
9218179 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen (AGT) gene M235T variant is associated with essential hypertension and elevated plasma AGT concentrations, although the underlying mechanisms are unknown.
|
9403548 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine whether the angiotensinogen M235T and angiotensin converting enzyme insertion/deletion (I/D) variants are related to the severity of hypertension in patients with established essential hypertension.
|
9170002 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that C-18T polymorphism in AGCE1 is a genetic risk factor for essential hypertension in the Japanese and is more tightly and directly associated with hypertension than TT/M235T.
|
9314411 |
1997 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study we examined the genotype frequencies of the insertion/deletion polymorphisms of the ACE gene and the M235T polymorphism of the Angiotensinogen (Agt) gene in patients with essential hypertension in comparison with normotensive subjects.
|
9524045 |
1998 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study shows that M235T and T174M variants are not associated either with essential hypertension or with target organ damage in a Spanish sample.
|
9607382 |
1998 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the interaction of the I/D ACE and M235T AGT polymorphic alleles can contribute to essential hypertension, despite the absence of single gene associations with the condition.
|
9607178 |
1998 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
According to combined haplotype analysis of diallele and microsatellite markers, it remains a possibility that M235T, T+31C, G-6A, A-20C and G-1074T polymorphisms may play an important role in increased risk for essential hypertension.
|
11191642 |
2000 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore investigated the association between ACE I/D, AGT M235T, and AT1 A1266C gene polymorphisms and early signs of target organ damage in 215 untreated patients with essential hypertension (EH).
|
10652033 |
2000 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common variant at codon 235 of the angiotensinogen gene with methionine to threonine amino acid substitution (AGT M235T) has been reported as a genetic risk for essential hypertension.
|
11230286 |
2001 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE (I/D) polymorphism showed no association with CHD, whereas the frequency distribution of AGT (M235T) genotypes among patients and controls (235T: 29.1% and 19.0%; M235T: 48.5% and 50.2%; M235: 22.4% and 30.8%, respectively) was statistically different (p = 0.005) and not related to the presence of essential hypertension.
|
11345362 |
2001 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the T235M polymorphism in the AGT product is associated with an increased risk of essential hypertension in multiple populations, making AGT a good example of a quantitative-trait locus underlying susceptibility to a common disease.
|
11731937 |
2002 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T polymorphism of the angiotensinogen gene (AGT) is associated with an increased risk of primary hypertension, which may then lead to progressive renal disease.
|
12164881 |
2002 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension.
|
12037699 |
2002 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of our study suggest an association of the M235T polymorphism in the gene encoding angiotensinogen with essential hypertension.
|
12169209 |
2003 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we examined the role of AGT promoter polymorphisms, including G-217A, A-6G and M235T variants, and their promoter function in essential hypertension in Taiwanese populations.
|
14597849 |
2003 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen (AGT) gene polymorphism M235T (a methionine to threonine amino acid substitution) has been investigated in association with essential hypertension (EHT) based on conventional measurement of blood pressure (BP); however, the results have been inconsistent.
|
12661912 |
2003 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether carotid artery stiffness was increased in patients with untreated essential hypertension who are homozygous for the T allele of the M235T polymorphism of the angiotensinogen (AGT) gene and in mutant mice carrying three copies of the angiotensinogen (Agt) gene.
|
15201545 |
2004 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Angiotensinogen M235T gene variants and its association with essential hypertension and plasma renin activity in Malaysian subjects: a case control study.
|
15811183 |
2005 |