|
Mood Disorders
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that there is no association between WFS1 gene H611R polymorphism and mood disorders.
|
25074416 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggested that the G allele of rs734312 polymorphism [dominant: FEM OR 0.873, 95%CI (0.810 - 0.940), recessive: FEM OR 0.876, 95% CI (0.800 - 0.959)] and A allele of rs10010131 polymorphism [dominant:FEM OR 0.853, 95% CI (0.817 - 0.892), recessive:REM OR 0.833, 95% CI (0.756 - 0.917)] in WFS1 gene had significant protective effects on risk of T2D.
|
23257691 |
2013 |
|
Mood Disorders
|
|
0.030 |
GeneticVariation
|
BEFREE |
If this finding will be replicated, the H611R polymorphism may be a possible marker for mood disorders in a psychiatric population, and not just in relatives of Wolfram syndrome probands.
|
19328217 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The WFS1 rs734312 showed a borderline significant association with type 2 diabetes with directions and relative risks consistent with previous reports.
|
18568334 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Four WFS1 SNPs (rs10010131, rs6446482, rs752854 and rs734312 [H611R]) were genotyped in a type 2 diabetes case-control study (n = 1,296/1,412) of Swedish adults.
|
18040659 |
2008 |
|
Mood Disorders
|
|
0.030 |
GeneticVariation
|
BEFREE |
Haplotype analysis revealed a common GTA haplotype, formed by SNPs 684C/G, 1185C/T and 1832G/A, conferring risk for affective disorders.
|
15473915 |
2005 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs734312 from WFS1 gene was associated with diabetes at genotype level (P<0.01).
|
24477584 |
2014 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs734312 from WFS1 gene was associated with diabetes at genotype level (P<0.01).
|
24477584 |
2014 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped the WFS1 SNPs rs10010131, rs752854 and rs734312 (H611R) in 3,548 DPP participants and performed Cox regression analysis using genotype, intervention and their interactions as predictors of diabetes incidence.
|
18060660 |
2008 |
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped the WFS1 SNPs rs10010131, rs752854 and rs734312 (H611R) in 3,548 DPP participants and performed Cox regression analysis using genotype, intervention and their interactions as predictors of diabetes incidence.
|
18060660 |
2008 |
|
Completed Suicide
|
|
0.010 |
GeneticVariation
|
BEFREE |
The nonsynonymous variants rs1383180 in EVC gene, rs6811863 in TBC1D1 gene, rs362272 in HTT gene, and rs734312 in WFS1 gene were associated to the male completed suicide.
|
19115052 |
2009 |
|
Suicidal
|
|
0.010 |
GeneticVariation
|
BEFREE |
The H611R polymorphism was associated with mood disorders but not suicidal behavior, aggressive/impulsive traits or suicidality in first-degree relatives.
|
19328217 |
2009 |
|
psychiatric hospitalization
|
|
0.010 |
GeneticVariation
|
BEFREE |
Wolframin gene polymorphisms, including the H611R polymorphism, are reportedly associated with mood disorders and psychiatric hospitalization, but there is disagreement about the association of this specific variant with suicidality and impulsive traits.
|
19328217 |
2009 |
|
Analgesic Overuse Headache
|
|
0.010 |
GeneticVariation
|
BEFREE |
To test the influence of WFS1 polymorphisms on medication overuse headache (MOH), a chronic headache condition related to symptomatic drugs overuse, we analyzed 82 MOH patients for the WFS1 His611Arg polymorphism, and performed a comparison between clinical features of Arg/Arg (R/R) and non-R/R individuals.
|
17719176 |
2007 |
|
Bipolar Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
None had the A559T and A602V mutations, and no association of G576S and H611R with bipolar disorder was found.
|
12565131 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
By genetic association studies of 185 type 1 diabetes patients and 380 control subjects, we found that R456H was significantly increased in the type 1 diabetes group compared to the control group (P = 0.0005); H611R and I720V were also significantly increased with weaker significance.
|
10679252 |
2000 |