|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis.
|
26419236 |
2016 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis.
|
25250621 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single genetic variant, PNPLA3 I148M, has been widely associated with increased hepatic steatosis.
|
22978414 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
General linear models were used to detect interactive effects between the PNPLA3 rs738409 genotype and 4 year changes in body weight on liver steatosis and glucose metabolism.
|
30673802 |
2019 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824-6.500, P < 0.001).
|
26139292 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study identified genetic polymorphism (rs738409 C>G) in the PNPLA3/adiponutrin gene associated with liver steatosis.
|
21334404 |
2011 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 GG genotype is positively associated with HS, while the IFNL3 rs 12979860 CC genotype may be negatively associated with HS, in Asian CHC patients.
|
28797039 |
2017 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies confirmed that the I148M variant predisposes towards the full spectrum of liver damage associated with fatty liver: from simple steatosis to steatohepatitis and progressive fibrosis.
|
24222941 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B.
|
23564580 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
This gain of function provides a plausible biochemical mechanism for the development of liver steatosis in subjects carrying the I148M variant.
|
22560221 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
There is an established correlation between the PNPLA3 rs738409 C > G single nucleotide polymorphism (SNP) and hepatic steatosis and fibrosis in hepatitis C virus (HCV) infected patients.
|
31642820 |
2019 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 minor allele c.444G represents a risk factor for liver steatosis and fibrosis progression also in chronic hepatitis C (HCV).
|
31527889 |
2019 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association between PNPLA3 rs738409/IL28B rs8099917 genotypes and hepatic steatosis or liver fibrosis was observed.
|
24349054 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults.
|
20546964 |
2010 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Before 2008, candidate gene studies based on prior knowledge of pathophysiology of fatty liver yielded conflicting results.In 2008, Romeo et al. published the first genome wide association study and reported the strongest genetic signal for the presence of fatty liver (PNPLA3, patatin-like phospholipase domain containing 3; rs738409).
|
22093607 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of PNPLA3 p.I148M with liver steatosis increased with the greater amount of abdominal fat, irrespective of BMI.
|
25986529 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
CT-defined fatty liver is common among men at risk for HIV infection and is associated with greater visceral adiposity, HOMA-IR, and PNPLA3 (rs738409).
|
24642579 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer.
|
24222094 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs738409 in PNPLA3 was significantly associated with liver density (P=0.0075) and hepatic steatosis (P=0.0350), but not with blood glucose, HbA(1c), total cholesterol, triglycerides, high-density or low-density lipoprotein levels or liver function tests (P=0.15-0.96).
|
21665509 |
2011 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants were independent risk factors of hepatic steatosis and elevated ALT levels.
|
29314568 |
2018 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of PNPLA3 rs738409 polymorphism with liver steatosis but not with cirrhosis in patients with HBV infection: Systematic review with meta-analysis.
|
29218813 |
2018 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis showed that PNPLA3 rs738409 polymorphism exerted strong influence not only on fatty liver but also on the histological injury.
|
30762732 |
2019 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we show that only in subjects with hepatic steatosis, the OXFAs are associated with the CK-18 and that this association is modulated by the PNPLA3 rs738409 variant.
|
23815500 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), PPP1R3B (rs4240624), TM6SF (rs8542926), LYPLAL1 (rs12137855) and MBOAT7 (rs626283) by RT-PCR in 117 HIV-positive patients on cART and stratified participants based on their "controlled attenuation parameter" (CAP) into probable (CAP: 215-300 dB/m) and definite (CAP >300 dB/m) hepatic steatosis.
|
28594920 |
2017 |