|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance.
|
24828988 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study identified genetic polymorphism (rs738409 C>G) in the PNPLA3/adiponutrin gene associated with liver steatosis.
|
21334404 |
2011 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single genetic variant, PNPLA3 I148M, has been widely associated with increased hepatic steatosis.
|
22978414 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), the rs738409, in the patatin like phospholipase 3 gene (PNPLA3) has been recently associated with increased hepatic steatosis and ALT levels in adults and children.
|
22629460 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among 270 HBV-infected patients, concurrent fatty liver was found in 107 patients (39.6%) and was associated with metabolic risks, cirrhosis (P = 0.016) and PNPLA3 rs738409 CG/GG genotype (P = 0.002).
|
27547913 |
2017 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824-6.500, P < 0.001).
|
26139292 |
2015 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of PNPLA3 rs738409 polymorphism with liver steatosis but not with cirrhosis in patients with HBV infection: Systematic review with meta-analysis.
|
29218813 |
2018 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between the rs738409 polymorphism of the PNPLA3 gene genotype GG and hepatic steatosis and advanced fibrosis were observed.
|
29258449 |
2017 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations of the single nucleotide polymorphisms (SNP) PNPLA3 rs738409 and TM6SF2 rs58542926 with hepatic steatosis have recently been established.
|
26847197 |
2016 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Before 2008, candidate gene studies based on prior knowledge of pathophysiology of fatty liver yielded conflicting results.In 2008, Romeo et al. published the first genome wide association study and reported the strongest genetic signal for the presence of fatty liver (PNPLA3, patatin-like phospholipase domain containing 3; rs738409).
|
22093607 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
CT-defined fatty liver is common among men at risk for HIV infection and is associated with greater visceral adiposity, HOMA-IR, and PNPLA3 (rs738409).
|
24642579 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expression of PNPLA3(I148M), but not PNPLA3(WT), in liver recapitulated the fatty liver phenotype as well as other metabolic features associated with this allele in humans.
|
23023705 |
2012 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
G allele carriers of the SNP rs738409 had higher liver fat (P < 0.0001) and an odds ratio of 2.38 (95% CI 1.37-4.20) for having fatty liver compared to C allele homozygotes.
|
19651814 |
2009 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
General linear models were used to detect interactive effects between the PNPLA3 rs738409 genotype and 4 year changes in body weight on liver steatosis and glucose metabolism.
|
30673802 |
2019 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Human immunodeficiency virus (HIV)-induced metabolic abnormalities and antiretroviral therapy (ART), genetic factors, most importantly the rs738409 C > G p.I148M variant in the patatin-like phospholipase domain containing 3 (PNPLA3)-gene, as well as hepatitis C virus (HCV) coinfection may all cause hepatic steatosis (HS).
|
31067123 |
2019 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we show that only in subjects with hepatic steatosis, the OXFAs are associated with the CK-18 and that this association is modulated by the PNPLA3 rs738409 variant.
|
23815500 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis showed that PNPLA3 rs738409 polymorphism exerted strong influence not only on fatty liver but also on the histological injury.
|
30762732 |
2019 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis.
|
25250621 |
2014 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association between PNPLA3 rs738409/IL28B rs8099917 genotypes and hepatic steatosis or liver fibrosis was observed.
|
24349054 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B.
|
23564580 |
2013 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis.
|
26419236 |
2016 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 G allele carriers were found to be more susceptible to the metabolic-related hepatic steatosis, and developed NAFLD and liver fibrosis despite presenting relatively better metabolic statuses and lower risks for carotid atherosclerosis.
|
26765961 |
2016 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants were independent risk factors of hepatic steatosis and elevated ALT levels.
|
29314568 |
2018 |
|
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 Polymorphism Predicts Development and Severity of Hepatic Steatosis but Not Metabolic Syndrome in Celiac Disease.
|
30189691 |
2018 |