|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genomic DNA of 294 patients with CP and 175 healthy/non-periodontitis controls were genotyped, using the real-time polymerase chain reaction (RT-PCR) method, for ApoE (rs429358 and rs7412) gene polymorphisms.
|
25545672 |
2015 |
|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Disease association analysis revealed a susceptibility haplotype CGTC (in order of rs440446, rs769450, rs429358, rs7412) and the carriers of this haplotype has higher risk of osteopenia (OR 3.53, 95% CI 1.21-11.0, P=0.017) and osteoporosis (OR 3.61, 95% CI 1.53-9.48, P=0.002) after adjusting the confounding effect of age, BMI and years since menopause.
|
20663622 |
2010 |
|
Osteopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Disease association analysis revealed a susceptibility haplotype CGTC (in order of rs440446, rs769450, rs429358, rs7412) and the carriers of this haplotype has higher risk of osteopenia (OR 3.53, 95% CI 1.21-11.0, P=0.017) and osteoporosis (OR 3.61, 95% CI 1.53-9.48, P=0.002) after adjusting the confounding effect of age, BMI and years since menopause.
|
20663622 |
2010 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Of the 3 SNPs most significantly associated with MI, rs7412, which defines the Apo E2 isoform, was associated with both a lower Apo B/A1 ratio (P=1.0x10(-7)) and lower MI risk (P=0.0004).
|
20031563 |
2009 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of <i>PCSK9</i> (rs562556), <i>APOE</i> (epsilon polymorphism, rs7412 and rs429358), <i>LPL</i> (rs320), <i>MTHFR</i> (rs1801133), <i>eNOS</i> (rs2070744), and the 9p21 region (rs1333049) in 405 patients with MI and 198 controls.
|
29340220 |
2019 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The association of the MS severity score (MSSS) and APOE rs429358 and rs7412 was assessed across 3237 MS patients using linear regression analyses.
|
26669675 |
2015 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Despite sufficient power to detect associations at genome-wide significance thresholds across a range of ORs, our analyses did not support a role of rs429358 or rs7412 on MS susceptibility.
|
22972946 |
2012 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrate that except of TG, Apo A5 T-1131C (rs662799) and Apo E (rs429358, rs7412) polymorphisms have no remarkable effect on MetS characteristics.
|
24709297 |
2014 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
|
20838585 |
2010 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.
|
23100282 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Very low-depth whole-genome sequencing in complex trait association studies.
|
30576415 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.
|
28548082 |
2017 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
SNP rs7412 in APOE was strongly associated with LDL-C in both datasets (p < 5 × 10(-8) ).
|
23067351 |
2012 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
|
24023260 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.
|
31675503 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic architecture of human plasma lipidome and its link to cardiovascular disease.
|
31551469 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
SNP rs7412 in APOE was strongly associated with LDL-C in both datasets (p < 5 × 10(-8) ).
|
23067351 |
2012 |
|
Longevity
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A meta-analysis of genome-wide association studies identifies multiple longevity genes.
|
31413261 |
2019 |
|
Lipoprotein (a) measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.
|
28512139 |
2017 |
|
Lipids measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Lipids measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |