|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
BEFREE |
In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported.
|
25041342 |
2015 |
|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
BEFREE |
No significant correlation was shown in HLA-DP rs3077 and rs9277535 with HBV infection or liver function recovery (P < .05).Our study concluded that HLA-DP (rs3077 and rs9277535) and HLA-DQ (rs7453920) were not significantly associated with HBV recurrence or HBV susceptibility, but HLA-DQ rs7453920 was related to prognosis of liver transplant recipients.
|
28640108 |
2017 |
|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
BEFREE |
The pooled risk estimates indicated that HLA-DQ rs7453920-A polymorphism was associated with decreased risk of HBV infection, and rs7453920-G serves as a risk factor in HBV infection.
|
28512640 |
2017 |
|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B virus (HBV) infection in Japanese populations.
|
22105689 |
2012 |
|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
BEFREE |
SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients.
|
28267888 |
2017 |
|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
BEFREE |
The SNPs of HLA-DQ (rs2856718 and rs7453920) were determined in 299 patients with chronic HBV infection.
|
27580643 |
2017 |
|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
BEFREE |
We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection.
|
24940741 |
2014 |
|
Hepatitis B
|
|
0.880 |
GeneticVariation
|
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Our data show that HLA gene polymorphisms are associated with SI in patients with HBV-related HCC, and the absence of minor allele A (rs7453920) promotes SI and shortens OS.
|
30104900 |
2018 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Logistic regression analyses showed that HLA-DQ rs2856718 significantly decreased host HCC risk, whereas three SNPs were associated with HBV clearance (HLA-DP rs9277535 as well as HLA-DQ rs7453920 and rs2856718).
|
22105689 |
2012 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
HLA-DP/DQ polymorphisms (rs3077, rs9277535, rs7453920) did not associate with HCC development, but did correlate with HBV susceptibility and HBV natural clearance.
|
25365208 |
2014 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
This study revealed an association between rs2856718 and HCC development and an association between rs7453920 and HBsAg levels.
|
27580643 |
2017 |
|
Liver carcinoma
|
|
0.740 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Hepatitis B, Chronic
|
|
0.720 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
Hepatitis B, Chronic
|
|
0.720 |
GeneticVariation
|
BEFREE |
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population.
|
28613373 |
2017 |
|
Hepatitis B, Chronic
|
|
0.720 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
Multiple Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggested that the functional HLA-DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB.
|
30600606 |
2019 |
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is the first study demonstrating the significant associations of SNP rs7453920 and the haplotypes in the HLA gene with the risk of AS in Southwest Chinese population.
|
27394003 |
2016 |
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
The HLA-DQ rs7453920 and -DP rs9277535 mutations were significantly associated with HCV infection susceptibility and chronicity, respectively.
|
29212520 |
2017 |
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of CHB with SNPs rs2856718 and rs7453920 remains significant even after stratification with rs3077 and rs9277535, indicating independent effect of HLA-DQ variants on CHB susceptibility (P-value of 1.52 × 10(-21)- 2.38 × 10(-30)).
|
21750111 |
2011 |
|
Hepatitis B, Chronic
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.700 |
GeneticVariation
|
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |